Registration Dossier
Registration Dossier
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EC number: 203-939-6 | CAS number: 112-14-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs: Acetate C-8
- Author:
- Edited by D. L. J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology. 12, 815, 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- 48-hr closed-patch test for substance was done out to find skin irritation effect of Acetate C-8 to human.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Octyl acetate
- EC Number:
- 203-939-6
- EC Name:
- Octyl acetate
- Cas Number:
- 112-14-1
- Molecular formula:
- C10H20O2
- IUPAC Name:
- octyl acetate
- Test material form:
- other: liquid
- Details on test material:
- Name of test material (as cited in study report): Octyl acetate
- Molecular formula: C10H20O2
- Molecular weight: 172.27 g/mol
- Smiles notation: C(CCCCCC)COC(C)=O
- InChI: 1S/C10H20O2/c1-3-4-5-6-7-8-9-12-10(2)11/h3-9H2,1-2H3
Substance type: Organic
Physical State: Liquid
Constituent 1
Test animals
- Species:
- human
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 8% in petrolatum
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- 48 hours
- Number of animals:
- no data
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 0
- Remarks on result:
- other: no irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- The substance Acetate C-8 is considered to be non-irritant to human at 8% concentration in petrolatum.
- Executive summary:
48-hr closed-patch test was carried out to find skin irritation effect of Acetate C-8. The material Acetate C-8 was tested at a concentration of 8% in petrolatum, it produce no irritation after a 48-h closed patch test. Therefore,The substance, Acetate C-8 is considered to be non-irritant to human skin.
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