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EC number: 202-058-4 | CAS number: 91-30-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
- Author:
- GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
- Year:
- 1 994
- Bibliographic source:
- Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
- Reference Type:
- review article or handbook
- Title:
- TOXICOLOGICAL EVALUATION of 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation study of 7-Amino-4-hydroxy-2-naphthalenesulfonic acid was carried out in rabbits to evaluate its irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- IUPAC Name:
- 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
- Reference substance name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 201-718-9
- EC Name:
- 7-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 87-02-5
- IUPAC Name:
- 7-amino-4-hydroxynaphthalene-2-sulfonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Weight at study initiation: 3 – 4kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
Area of exposure: inner surface of ears
% coverage: Not mentioned
Type of wrap if used: under an adhesive
dressing
REMOVAL OF TEST SUBSTANCE
Washing (if done): the test substance was washed off with water and soap/vegetable oil.
Time after start of exposure: after the exposure period
SCORING SYSTEM: Not mentioned
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days
- Reversibility:
- no data
- Remarks on result:
- other: Not irritating
- Irritant / corrosive response data:
- No irritation was observed in treated animals during the 7 days observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance 7-Amino-4-hydroxy-2-naphthalenesulfonic acid 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) was considered to be not irritating to rabbit skin.
- Executive summary:
The skin irritation test was performed in 2 New Zealand White rabbits (male and female) to assess the skin irritation potency of test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) for the observation period of 7 days.
In this skin irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid was applied to the inner surface of the ears of 2 rabbits. The test chemical was applied under an adhesive dressing for 24 hours.
At the end of the exposure period, the test substance was washed off with water and soap/vegetable oil. The observation period was 7 days.
No skin irritation was observed after 7 days.Hence the test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5)
can be considered as non-irritant to rabbit skin
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