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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data from publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
TOXICITY AND ECOTOXICITY OF SULFONIC ACIDS: STRUCTURE-ACTIVITY RELATIONSHIP
Author:
GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER
Year:
1994
Bibliographic source:
Chemosphere. Vol. 28, No. 12, pp. 2203.2236, 1994
Reference Type:
review article or handbook
Title:
TOXICOLOGICAL EVALUATION of 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of 7-Amino-4-hydroxy-2-naphthalenesulfonic acid was carried out in rabbits to evaluate its irritation potential.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
7-Amino-4-hydroxy-2-naphthalenesulfonic acid
IUPAC Name:
7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Constituent 2
Reference substance name:
7-amino-4-hydroxynaphthalene-2-sulphonic acid
EC Number:
201-718-9
EC Name:
7-amino-4-hydroxynaphthalene-2-sulphonic acid
Cas Number:
87-02-5
IUPAC Name:
7-amino-4-hydroxynaphthalene-2-sulfonic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material (as cited in study report): 7-Amino-4-hydroxy-2-naphthalenesulfonic acid
Molecular formula: C10H9NO4S
Molecular weight: 239.25g/mol
Substance type: organic
Physical state: solid

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
Weight at study initiation: 3 – 4kg

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 hours
Observation period:
7 days
Number of animals:
2
Details on study design:
TEST SITE
Area of exposure: inner surface of ears
% coverage: Not mentioned
Type of wrap if used: under an adhesive
dressing

REMOVAL OF TEST SUBSTANCE
Washing (if done): the test substance was washed off with water and soap/vegetable oil.
Time after start of exposure: after the exposure period

SCORING SYSTEM: Not mentioned

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 7 days
Reversibility:
no data
Remarks on result:
other: Not irritating
Irritant / corrosive response data:
No irritation was observed in treated animals during the 7 days observation period.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance 7-Amino-4-hydroxy-2-naphthalenesulfonic acid 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) was considered to be not irritating to rabbit skin.
Executive summary:

The skin irritation test was performed in 2 New Zealand White rabbits (male and female) to assess the skin irritation potency of test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5) for the observation period of 7 days.

 

In this skin irritation study, approx. 500 mg 7-amino-4-hydroxy-2-naphthalenesulfonic acid was applied to the inner surface of the ears of 2 rabbits. The test chemical was applied under an adhesive dressing for 24 hours.

 

At the end of the exposure period, the test substance was washed off with water and soap/vegetable oil. The observation period was 7 days.

 

No skin irritation was observed after 7 days.Hence the test chemical 7-Amino-4-hydroxy-2-naphthalenesulfonic acid (CAS No: 87-02-5)

can be considered as non-irritant to rabbit skin

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