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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: data from safety reports

Data source

Reference
Reference Type:
review article or handbook
Title:
TOXICOLOGICAL EVALUATION of 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid
Author:
BG Chemie
Year:
2000
Bibliographic source:
BG Chemie InfoCenter, TOXIKOLOGISCHE BEWERTUNGEN; TOXICOLOGICAL EVALUATION last updated: 06/2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Evaluation of eye irritation effect of 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid in rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
EC Number:
202-000-8
EC Name:
6-amino-4-hydroxynaphthalene-2-sulphonic acid
Cas Number:
90-51-7
IUPAC Name:
6-amino-4-hydroxynaphthalene-2-sulfonic acid
Constituent 2
Reference substance name:
2-Amino-8-hydroxynaphthalene-6-sulfonic acid
IUPAC Name:
2-Amino-8-hydroxynaphthalene-6-sulfonic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid
- Molecular formula (if other than submission substance): C10H9NO4S
- Molecular weight (if other than submission substance): 239.25g/mol
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
50 mg (the test chemical was dry and ground, made into paste with water)
Duration of treatment / exposure:
no data
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 7 days
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: no irritating effect on the eye.
Irritant / corrosive response data:
Slight reddening which had cleared up completely after 3 days, was seen in one of the 2 exposed rabbits one hour after application.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid is considered not irritating to rabbit eyes.
Executive summary:

Eye irritation test of 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid was conducted in rabbit. 50 mg of test chemical was instilled into the conjunctival sac of 2 rabbits. One hour after application, slight reddening was observed, which cleared up completely after 3 days Hence, the substance 6-Amino-4-hydroxy-2-naphthalene-6-sulfonic acid was considered to be not irritating to rabbit eyes.

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