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EC number: 210-412-4 | CAS number: 615-16-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-04-22 to 1986-04-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD and GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-hydroxybenzimidazole
- EC Number:
- 210-412-4
- EC Name:
- 2-hydroxybenzimidazole
- Cas Number:
- 615-16-7
- Molecular formula:
- C7H6N2O
- IUPAC Name:
- 2-hydroxybenzimidazole
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Polyethylenglycol 400
- Controls:
- no
- Amount / concentration applied:
- 500 mg Benzimidazolon in 0.35 ml Polyethylenglycol
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- total of 72 hrs
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 30-60 min
- Score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 30 - 60 min
- Score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 30 - 60 min
- Score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal: each #1, 2 and 3
- Time point:
- other: 24 hrs, 48 hrs, 72 hrs
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: each #1, 2 and 3
- Time point:
- other: 30- 60 min, 24 hrs, 48 hrs, 72 hrs
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- With reference to the present study the test item is neither a skin irritant nor corrosive to skin.
- Executive summary:
With reference to the present study the test item is neither a skin irritant nor corrosive to skin.
The judgement is based on the mean (of 24, 48 and 72 h) dermal irritation scores tabulated below:
Erythema (animal # 1/2/3): 0.0/0.0/0.0
Oedema (animal # 1/2/3): 0.0/0.0/0.0
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