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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

The test substance revealed negative results in a recent Bacterial Reversed Mutation Test with and without metabolic activation. Positive results were found when testing an ancient test sample with a purity of 83.3% and unknown impurities. Because of unproven substance sameness the latter result was not adequate for hazard assessment. Based on that it is concluded that 2-hydroxybenzimidazole caused negative results in the Bacterial Reversed Mutation Test.

Short description of key information:
OECD 471 AMES (KEY_471_2009_HARLAN_1218502): negative
OECD 471 AMES (NON-KEY_471_1991_HOECHST_91.0465): positive

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Findings in genetic toxicity studies i.e. negative results in the AMES Test in the absence and presence of metabolic activation do not meet criteria for classification according to 67/548/EEC (2.2 DSD-DPD) or REGULATION (EC) No 1272/2008 (2.1 GHS). Therefore classification is not warrantable.