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EC number: 212-889-4 | CAS number: 877-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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Endpoint summary
Administrative data
Description of key information
1, 2-Benzenedicarboxylic acid, monopotassium salt (CAS no 877-24-7) is likely to be non hazardous by oral route of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of 1,2-Benzenedicarboxylic acid, monopotassium salt in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- Name: 1,2-Benzenedicarboxylic acid, monopotassium salt
Molecular Formulas: C8H5O4.K
C8H6O4.K
Molecular Weight: 204.221 g/mole - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3200 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rats at 3200 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not Classified
- Conclusions:
- LD50 was considered to >3200 mg/kg bw when rats were treated with 1,2-Benzenedicarboxylic acid, monopotassium salt orally.
- Executive summary:
In a acute oral toxicity study, rats were treated with1,2-Benzenedicarboxylic acid, monopotassium salt in the concentration of 3200 mg/kg bw. No mortality was observed in treated rats at 3200 mg/kg bw.Therefore,LD50 was considered to >3200 mg/kg bw when rats were treated with1,2-Benzenedicarboxylic acid, monopotassium salt orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 200 mg/kg bw
- Quality of whole database:
- Data is Klimischh 2 and from RTECS database and SAX: Chemical Card
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
Based on the data available for target 1,2-Benzenedicarboxylic acid, monopotassium salt (CAS no 877-24-7) and its read across Phthalic acid (CAS no 88-99-3) is summarized below
In a study given by RTECS database (2017) and SAX: Chemical Card (2012), acute oral toxicity was given for rats by using 1,2-Benzenedicarboxylic acid, monopotassium salt in the concentration of 3200 mg/kg bw. No mortality was observed in treated rats at 3200 mg/kg bw. Therefore, LD50 was considered to >3200 mg/kg bw when rats were treated with 1,2-Benzenedicarboxylic acid, monopotassium salt orally.
Based on the prediction done by using QSAR Toolbox 3.4 (2017), acute oral toxicity was estimated in rats by using potassium biphthalate orally. 50 % mortality was observed at 4447.6 mg/kg bw in treated rats. Therefore, estimated LD50 was considered to be 4447.6 mg/kg bw when rat were treated with potassium biphthalate orally.
Based on the prediction done by using Danish QSAR (2017), acute oral toxicity was estimation done by in mice and rats by using potassium hydrogen phthalate at 2400 and 3500 mg/kg bw orally. 50 % mortality was observed at 2400 and 3500 mg/kg bw. Therefore, estimated LD50 was considered to be 2400 mg/kg bw for mice and 3500 mg/kg bw for rats when mice and rat were treated with potassium hydrogen phthalate orally.
In a study conducted by Schonekeret al(2003) for read across, acute oral toxicity was evaluated in Albino male and female mice by using Phthalic acid in the concentration of 5000 mg/kg bw orally by gavage in 5% gum acacia. No mortality was observed in treated mice at 5000 mg/kg bw. CNS depression and Inflammation of the gastrointestinal tract was observed in treated mice. Therefore, LD50 was considered to >5000 mg/kg bw when Albino male and female mice were treated with Phthalic acid orally by gavage.
Based on the data available for target 1, 2-Benzenedicarboxylic acid, monopotassium salt (CAS no 877-24-7) and its read across Phthalic acid (CAS no 88-99-3) is likely to be non hazardous by oral route of exposure.
Justification for classification or non-classification
Based on the data available for target 1, 2-Benzenedicarboxylic acid, monopotassium salt (CAS no 877-24-7) and its read across Phthalic acid (CAS no 88-99-3) is likely to be non hazardous by oral route of exposure.
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