Registration Dossier
Registration Dossier
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EC number: 203-397-0 | CAS number: 106-43-4
Endpoint summary
Administrative data
Description of key information
In 2 valid studies an oral LD50 ca. 2273 mg/kg bw (rat, male) and LD50 = 2389 mg/kg bw (rat, female) were found.
For acute dermal toxicity a LD50 > 5000 mg/kg bw was determined in 2 valid dermal toxicity test.
An inhalation-hazard test is available for acute inhalation toxicity. Rats exposed for 4182.6ppm (ca. 22000 mg/m³) for 4 hours 0/6 animals died. Rats exposed to 3950.9 ppm (ca. 21578 mg/m³) for 5 hours 3/6 animals died. Rats exposed to 3950.9 ppm (ca. 20781 mg/m³) or 4304.2 ppm (ca. or 4304.2 ppm (ca.22640 mg/m³) for 6 or 8 hours 6/6 animals died.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 273 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
The LD50 for acute oral toxicity is > 2000 mg/kg bw and the LD50 for acute dermal toxicity is > 5000 mg/kg bw.
For acute inhalation toxicity an inhalation-hazarzd test was conducted. The time- response curve seems to be very steep.
0/6 animals died after an exposure for 4 hours to ca. 22 mg/L, 3/6 rats died after an exposure for 5 hours to 21.5 mg/L.
All rats died after an exposure of 6 or 8 hours to ca. 20.7 or 22.6 mg/L, respectively.
Justification for classification or non-classification
Due to the results of the acute oral and dermal toxicity studies a classification is not justified.
According to Annex I to Directive 67/548/EEC p-chlorotoluene is classified as Xn, R 20; GHS: Acute Tox 4, H332
This classification will be adopted
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