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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In 2 valid studies an oral LD50 ca. 2273 mg/kg bw (rat, male) and LD50 = 2389 mg/kg bw  (rat, female) were found. 
For acute dermal toxicity a LD50 > 5000 mg/kg bw was determined in 2 valid dermal toxicity test.
An inhalation-hazard test is available for acute inhalation toxicity. Rats exposed for 4182.6ppm (ca. 22000 mg/m³) for 4 hours 0/6 animals died. Rats exposed to 3950.9 ppm (ca. 21578 mg/m³) for 5 hours 3/6 animals died. Rats exposed to 3950.9 ppm (ca. 20781 mg/m³) or 4304.2 ppm (ca. or 4304.2 ppm (ca.22640 mg/m³) for 6 or 8 hours 6/6 animals died.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
2 273 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
5 000 mg/kg bw

Additional information

The LD50 for acute oral toxicity is > 2000 mg/kg bw and the LD50 for acute dermal toxicity is > 5000 mg/kg bw.

For acute inhalation toxicity an inhalation-hazarzd test was conducted. The time- response curve seems to be very steep.

0/6 animals died after an exposure for 4 hours to ca. 22 mg/L, 3/6 rats died after an exposure for 5 hours to 21.5 mg/L.

All rats died after an exposure of 6 or 8 hours to ca. 20.7 or 22.6 mg/L, respectively.

Justification for classification or non-classification

Due to the results of the acute oral and dermal toxicity studies a classification is not justified.

According to Annex I to Directive 67/548/EEC p-chlorotoluene is classified as Xn, R 20; GHS: Acute Tox 4, H332

This classification will be adopted