Registration Dossier
Registration Dossier
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EC number: 203-106-7 | CAS number: 103-38-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- D. L. J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology,1974
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- T.B.Adams et. al.
- Year:
- 2 005
- Bibliographic source:
- Food and Chemical Toxicology,2005
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- World Health Organization
- Year:
- 2 002
- Bibliographic source:
- WHO,2002
- Reference Type:
- other: secondary source
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
Test material
- Reference substance name:
- Benzyl isovalerate
- EC Number:
- 203-106-7
- EC Name:
- Benzyl isovalerate
- Cas Number:
- 103-38-8
- Molecular formula:
- C12H16O2
- IUPAC Name:
- benzyl 3-methylbutanoate
- Test material form:
- liquid
- Details on test material:
- Name of the test material: Benzyl isovalerate
- Molecular formula: C12H16O2
- Molecular Weight: 192.2564 g/mol
- Substance type: Organic
- Smiles: c1(COC(CC(C)C)=O)ccccc1
-Physical State: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in rats at 5000 mg/kg
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be>5000 mg/kg,when rats were treated with test chemical orally.
- Executive summary:
In a acute oral toxicity study,rats were treated with test chemical in the concentration of 5000 mg/kg bw orally.No mortality observed at 5000 mg/kg. Therefore,LD50 was considered to be >5000 mg/kg,when rats were treated with test chemical orally.
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