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Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology,1974
Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical in rats
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
T.B.Adams et. al.
Year:
2005
Bibliographic source:
Food and Chemical Toxicology,2005
Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
World Health Organization
Year:
2002
Bibliographic source:
WHO,2002
Reference Type:
other: secondary source
Title:
Acute oral toxicity of test chemical in rats
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl isovalerate
EC Number:
203-106-7
EC Name:
Benzyl isovalerate
Cas Number:
103-38-8
Molecular formula:
C12H16O2
IUPAC Name:
benzyl 3-methylbutanoate
Test material form:
liquid
Details on test material:
Name of the test material: Benzyl isovalerate
- Molecular formula: C12H16O2
- Molecular Weight: 192.2564 g/mol
- Substance type: Organic
- Smiles: c1(COC(CC(C)C)=O)ccccc1
-Physical State: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in rats at 5000 mg/kg
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be>5000 mg/kg,when rats were treated with test chemical orally.
Executive summary:

In a acute oral toxicity study,rats were treated with test chemical in the concentration of 5000 mg/kg bw orally.No mortality observed at 5000 mg/kg. Therefore,LD50 was considered to be >5000 mg/kg,when rats were treated with test chemical orally.