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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Monograph on fragrance raw material-Geranyl nitrile
Author:
Wohl
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Pages 787

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: refer below principle
Principles of method if other than guideline:
The acute toxicity study has been performed on rabbits by dermal route.
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethylocta-2,6-dienenitrile
EC Number:
225-918-0
EC Name:
3,7-dimethylocta-2,6-dienenitrile
Cas Number:
5146-66-7
Molecular formula:
C10H15N
IUPAC Name:
3,7-dimethylocta-2,6-dienenitrile
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): GERANYL NITRILE
- Molecular formula (if other than submission substance): C10H15N
- Molecular weight (if other than submission substance): 149.236 g/mole
- Smiles notation (if other than submission substance): N#C\C=C(\CC\C=C(\C)C)C
- InChl (if other than submission substance): 1S/C10H15N/c1-9(2)5-4-6-10(3)7-8-11/h5,7H,4,6H2,1-3H3/b10-7+
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
4300 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality
Mortality:
50% mortality occurred
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 4300 mg/kg bw when rabbits were treated with Geranyl nitrile by dermal application.
Executive summary:

In a acute dermal toxicity study, rabbits were treated with Geranyl nitrile in the concentration of 4300 mg/kg bw by dermal application. 50 % mortality observed in 4300 mg/kg bw treated rats. Therefore, LD50 was considered to be 4300 mg/kg bw when rabbits were treated with Geranyl nitrile by dermal application.