Registration Dossier
Registration Dossier
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EC number: 225-918-0 | CAS number: 5146-66-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Monograph on fragrance raw material-Geranyl nitrile
- Author:
- Wohl
- Year:
- 1 976
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Pages 787
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- The acute toxicity study has been performed on rabbits by dermal route.
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- 3,7-dimethylocta-2,6-dienenitrile
- EC Number:
- 225-918-0
- EC Name:
- 3,7-dimethylocta-2,6-dienenitrile
- Cas Number:
- 5146-66-7
- Molecular formula:
- C10H15N
- IUPAC Name:
- 3,7-dimethylocta-2,6-dienenitrile
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): GERANYL NITRILE
- Molecular formula (if other than submission substance): C10H15N
- Molecular weight (if other than submission substance): 149.236 g/mole
- Smiles notation (if other than submission substance): N#C\C=C(\CC\C=C(\C)C)C
- InChl (if other than submission substance): 1S/C10H15N/c1-9(2)5-4-6-10(3)7-8-11/h5,7H,4,6H2,1-3H3/b10-7+
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no data
- Duration of exposure:
- no data
- Doses:
- 4300 mg/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality
- Mortality:
- 50% mortality occurred
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 4300 mg/kg bw when rabbits were treated with Geranyl nitrile by dermal application.
- Executive summary:
In a acute dermal toxicity study, rabbits were treated with Geranyl nitrile in the concentration of 4300 mg/kg bw by dermal application. 50 % mortality observed in 4300 mg/kg bw treated rats. Therefore, LD50 was considered to be 4300 mg/kg bw when rabbits were treated with Geranyl nitrile by dermal application.
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