Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Executive summary:
Preliminary investigations (non-GLP) for the determination of the adsorption coefficient KOC of
LICOCARE RBW 106 FL VITA on soil and on sewage sludge using high performance liquid
chromatography (HPLC) were performed according to OECD 121 and Council Regulation (EC)
No.440/2008, Method C.19 at Noack Laboratorien GmbH, 31157 Sarstedt, Germany. The
conducted experiments showed, that the evaluation of individual log Koc of the test item
components is not feasible a cyanopropyl analytical column.
As the test item is a UVCB substance with contents of < 1 % to 8.1 % of the individual components
and with regard to the low solubility, the determination of the adsorption / desorption behavior
using a batch equilibrium method, acc. to OECD 106 (2000) and Council Regulation (EC) No.
440/2008, C.18 (2008), is also not feasible.- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- The adsorption Coefficient (Koc) of the test substance LICOCARE RBW 106 was determined by the HPLC method. During the test, there was no peak detected. It was considered that the test method was not suitable for the test substance and the test was terminated.
- Executive summary:
According to “Ministry of environmental protection of the people's Republic of China, The Guidelines for the Testing of Chemicals -Physical-Chemical Properties and Physical Hazards, 2013, 121 Estimation of the Adsorption Coefficient (Koc ) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)” and “OECD Guidelines for Testing of Chemicals, 121 Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC), 2001”, the adsorption coefficient (Koc) of LICOCARE RBW 106 (KLEC20191126-2958) was determined using HPLC method.
Based on the information from the sponsor ,the test substance is petrochemical products and belong to none unique and identified molecular structure substance. The main contents of the the substance are short chain to long chain alkanes (C6-C32). Based on the analysis method and the physicial-chemical property of the test substance, gas chromatography method would be used for this type of substance. Reverse phase liquid chromatography should be used in this method and the mobile phase which is recomend by the test guidline is methanol/water mixtures and the ratio is 55:45. If methanol/water mixtures are not appropriate, other organic solvent/water mixtures may be tried. During this test, four different mobile phase systems of methanol-water(55:45), methanol, methanol-tetrahydrofuran (50:50) and tetrahydrofuran were used. Uv detector or UV diode array detector would be used to detect the test substance. As the test sustance belongs to alkane without ultraviolet absorption, it may not detected by the detector.
The test substance is not soluble in water nor most of the solvent that commonly used in HPLC. It is soluble in tetrahydrofuran when the temperture increased to 60℃. A stock solution with a nominal concentration of 1902mg/L was prepared by adding the test sustance in T tetrahydrofuran at 60℃. And the working solutions of 19mg/L and 38mg/L were prepared by dilutting with methanol, because the working solution is clear within a certain limit when diluted by methanol. The test substance was run in four different mobile phase systems of methanol-water (55:45), methanol, methanol-tetrahydrofuran (50:50) and tetrahydrofuran for 60 minutes, respectively. There was no peak detected. Estimation of the Adsorption Coefficient (Koc) by HPLC is not suitable for LICOCARE RBW 106 and the test was terminated.
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Executive summary:
According to “Ministry of environmental protection of the people's Republic of China, The Guidelines for the Testing of Chemicals-Physical-Chemical Properties and Physical Hazards, 2013, 106 Adsorption-Desorption Using a Batch Equilibrium Method” and “OECD, Guidelines for the Testing of Chemicals. Adsorption-Desorption Using a Batch Equilibrium Method 106, 2000”, the adsorption/desorption test of the test substance LICOCARE RBW 106 (KLEC20200520-2958) was determined.
According to the information provided by the sponsor, the test substance is a multi-component mixture, hardly soluble in water, and the solubility in water is 2mg/L. Accurately weighed 10.77mg test substance, then the test substance was prepared in 100mL 0.01mol/L CaCl2 solution, and stirred (via magnetic stirrer) at the rate of 500rpmin the dark for 24h followed by filtration using a 0.22μm membrane to make a saturated solution of the test substance in test system as the stock solution. The result of the GC analysis showed that the concentrations of the test substance in the stock solution were less than the limit of detection of instrumen t(LOD, LOD=10.0mg/L). According to “Ministry of environmental protection of the people's Republic of China, The Guidelines for the Testing of Chemicals-Physical-Chemical Properties and Physical Hazards, 2013, 106 Adsorption-Desorption Using a Batch Equilibrium Method” and “OECD, Guidelines for the Testing of Chemicals. Adsorption-Desorption Using a Batch Equilibrium Method 106, 2000”, the concentration of the stock solution of the test substance should be 3 orders of magnitude higher than the detection limit of the analytical method, and the solubility of the test substance in 0.01mol/L CaCl2 solution is not sufficient for the test. The adsorption/desorption test of the test substance LICOCARE RBW 106 (KLEC20200520-2958) could not be carried out.
Referenceopen allclose all
Description of key information
Adsoprtion / Desorption studies according OECD 121 and OECD 106 are technically not possible. Three tests to perform studies have failed. Therefore the Koc value can only be estimated.
Koc = 0.41 x Kow
log Koc = log Kow – 0.39
That means log Koc in a range of 0.91 to 2.11
For complex mixtures (e.g. UVCBs), a single value of Koc will not be definitive.
In such cases a range of values or a representative value can be given, depending on the
substance. Chapter R.7a: Endpoint specific guidance
Key value for chemical safety assessment
Additional information
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