(E)-2-methoxy-4-(prop-1-enyl)phenol

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 February - 22 April, 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with isomer purity. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP compliance programme (inspected on 05 February 2014 / signed on 07 October 2015)

Type of method:

method according to Siwoloboff

Key result

Decomposition:

yes

Decomp. temp.:

> 130 °C

Remarks on result:

other: boiling temperature of test substance was not determinable, as the test substance decomposed at temperatures above approximately 130°C, under normal atmospheric pressure, before boiling.

The trial determination showed an approximate decomposition point of 140 °C. When heating was continued in this preliminary test, the decomposed sample appeared to boil at approximately 270 °C.

The results of duplicate definitive boiling point determinations on test substance were as follows:

Barometric pressure: 1033 mbar.

As the boiling tubes were heated at 1 °C /minute, both samples were observed to darken above approximately 130 °C, indicating decomposition. In the case of decomposition, correction is considered superfluous as the determination of decomposition is slightly subjective and can only be regarded as an approximate value.

Executive summary:

The boiling point of the test substance was measured under GLP according to OECD 103 / EU A2 guideline, Siwoloboff (capillary) method.

The results of duplicate definitive boiling point determinations on test substance were as follows:

As the boiling tubes were heated at 1°C /minute, both samples were observed to darken above approximately 130 °C, indicating decomposition.

 

The boiling temperature of the test substance was not determinable, as the test substance decomposed at temperatures above approximately 130 °C, under normal atmospheric pressure, before boiling.

Description of key information

Decomposes (darkening) from ca 130°C before boiling. With prolonged heating, residue boils at ca 270°C.

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EU method, is available. It is considered as a key study. As decomposition was observed, no key value will be retained.