(E)-2-methoxy-4-(prop-1-enyl)phenol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted according to an internationally recognised method, with some non-critical deviations. The substance is considered to be adequately characterised with its purity. Therefore validation applies with restrictions.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

loading rate

Principles of method if other than guideline:

Not applicable

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

709 mg/L

Conc. based on:

test mat. (dissolved fraction)

Loading of aqueous phase:

20 g/L

Incubation duration:

24 - 72 h

Temp.:

20 °C

pH:

5

mg/L	24 h	48 h	72 h	pH
flask 1	796 787 781 mean 788	770 769 768 mean 769	791 733 728 mean 750	5.0
flask 2	778 773 773 mean 774	622 621 623 mean 622	645 638 639 mean 641	5.0
flask 3	718 730 725 mean 724	590 588 588 mean 589	723 725 730 mean 726	5.0
average +/-SD (%RSD)	762  +/- 34 (4.4%)	660  +/- 96 (14.5%)	706  +/- 58 (8.2%)
	709

No increasing tendency was observed, and results are within the acceptable variability limit of 15% (-13% between 24 and 48h), therefore the mean of all results was retained.

Conclusions:

Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)

Executive summary:

The water solubility of the test substance was measured according to EU method A6, flask method, with some non-critical deviations. Three flasks, with a loading rate of 20 g/L were presaturated at 30°C, and equilibrated for at 20°C. Each flask was sampled at 24, 48 and 72h, and each sample analysed in triplicate with HPLC. Results show variability, but in the acceptable range, so the mean value was retained.

The water solubility of the test substance was determined to be 709 mg/L (pH 5).

Description of key information

Considered as moderately soluble, with equilibrium reached from =< 24h. pH of saturated solution: 5.0.

Key value for chemical safety assessment

Water solubility:

709 mg/L

at the temperature of:

20 °C

Additional information

A reliable experimental study, conducted similarly to OECD method, is available. Despite restrictions (deviations leading to inaccuracy) it is considered as a key study. The result is retained as key data.