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additional toxicological information
Adequacy of study:
other information

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicodynamic properties of toluidines in chronic poisoning Part 1 Experiments on animals maintained on protein-rich diet
Author:
Malik-Brys, M., Senczuk, W.,
Year:
1995
Bibliographic source:
Bromatologia I Chemia|Toksykologiczna 28, 67-71
Reference Type:
publication
Title:
Toxicodynamic properties of toluidines in chronic poisoning Part II Tests on animals maintained on low-protein diet
Author:
Malik-Byrs M, Senczuk W
Year:
1995
Bibliographic source:
Bromatologia I Chemia|Toksykologiczna 28, 175-178

Materials and methods

Type of study / information:
Type: other: toxicodynamic properties in chronic poisoning

Test material

Constituent 1
Chemical structure
Reference substance name:
m-toluidine
EC Number:
203-583-1
EC Name:
m-toluidine
Cas Number:
108-44-1
Molecular formula:
C7H9N
IUPAC Name:
m-toluidine

Results and discussion

Any other information on results incl. tables

Aim of study was to assess delayed toxic effects of toluidine isomers during prolonged exposure in female Wistar rats.

1) Isomers were added to food containing 24% protein. Within the dose and exposure-duration range used, o-toluidine reached highest blood and urine concentration

2) Toluidines were added to food containing 8% protein. Within the ranges of doses and exposure times used in the experimentsthe highest blood and urine concentrations were recorded for o-toluidine and the lowest for p-toluidine (from english abstract of polish paper).

Applicant's summary and conclusion

Conclusions:
Aim of study was to assess delayed toxic effects of toluidine isomers during prolonged exposure in female Wistar rats.
1) Isomers were added to food containing 24% protein. Within the dose and exposure-duration range used, o-toluidine reached highest blood and urine concentration
2) Toluidines were added to food containing 8% protein. Within the ranges of doses and exposure times used in the experimentsthe highest blood and urine concentrations were recorded for o-toluidine and the lowest for p-toluidine (from english abstract of polish paper).

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