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EC number: 247-979-2 | CAS number: 26761-45-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study report presented sufficient experimental detail, however, it was not conducted according to a testing guideline or under the GLP regulations.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- Standard Franz difussion cell methodology with radio-labeled 2,3-epoxypropyl neodecanoate isomer was used.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3-epoxypropyl neodecanoate
- EC Number:
- 247-979-2
- EC Name:
- 2,3-epoxypropyl neodecanoate
- Cas Number:
- 26761-45-5
- Molecular formula:
- C13H24O3
- IUPAC Name:
- (oxiran-2-yl)methyl 2,2-dimethyloctanoate
- Test material form:
- other: Liquid at room temperature.
- Details on test material:
- The pure 14C labeled test substance was 2,3-epoxypropyl-3-carboxy-3,6-dimethyl heptanoate, the predominate isomer of 2,3-epoxypropyl neodecanoate.
Constituent 1
- Specific details on test material used for the study:
- See IUCLID Section 1.2 and 1.4
- Radiolabelling:
- yes
- Remarks:
- 14C-2,3-epoxypropyl neodecanoate isomer
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male C3H mice also served as a source of skin. Fisher 344 rats (approximately 250 gm) and male C3H mice (approximately 25 gm) were obtained from the Central Laboratories for the Blood Banks (CLB), Amsterdam, The Netherlands. Animals were kept on a 12 h light/dark cycle in humidity (60±15% relative humidity) and temperature (22±2°C) controlled mass-air-displacement rooms and following an acclimation period of 1 week were used as the source for skin. A standard rodent diet and deionized water were supplied ad libitum. Fresh full thickness healthy human breast skin was obtained from patients undergoing mammoplastic reduction surgery in a regional hospital, MCA, Alkmaar, The Netherlands.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- DMSO
- Duration of exposure:
- At least 24 hr.
- Doses:
- Five uL neat
- No. of animals per group:
- Study was in vitro.
- Control animals:
- no
- Details on study design:
- Study was conducted in vitro, see below.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Remarks:
- test system was in vitro.
- Dermal irritation:
- not specified
- Remarks:
- test system was in vitro.
- Absorption in different matrices:
- The amount of absorption in the in vitro difussion system was enhanced by the additon of 2.5 BSA to the receptor fluid.
- Total recovery:
- No data
Percutaneous absorption
- Dose:
- 5 uL neat test substance isomer.
- Parameter:
- percentage
- Absorption:
- ca. 0.2 %
- Remarks on result:
- other: 24 hr
- Remarks:
- for human skin samples.
- Conversion factor human vs. animal skin:
- No data
Applicant's summary and conclusion
- Conclusions:
- The data demonstrated that the 2,3-epoxypropyl neodecanoate isomer was metabolized in vitro in skin samples from rat, mouse and humans to the corresponding diol and ester hydrolysis product. Rat skin was most permeable to the test substance isomer. Human skin samples were approximately an-order-of-magnitude less permeable than rodent skin.
- Executive summary:
The dermal penetration and metabolism of radio-labeled 2,3 -epoxypropyl neodecanoate isomer was assessed in vitro using diffison cell technology with skin samples from rats, mice and humans. The data demonstrated that the 2,3-epoxypropyl neodecanoate isomer was metabolized in vitro in skin samples from rat, mouse and humans to the corresponding diol and ester hydrolysis product. Rat skin was most permeable to the test substance isomer. Human skin samples were approximately an-order-of-magnitude less permeable to the 2,3 -epoxypropyl neodecanoate isomer than rodent skin.
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