Registration Dossier
Registration Dossier
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EC number: 203-116-1 | CAS number: 103-48-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-11-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 1989
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.5
- Temp.:
- 35 °C
- pH:
- ca.
- Remarks on result:
- other: neutral
- Remarks:
- mobile phase: acetonitrile/water 60 : 40 (v/v)
- Conclusions:
- The partition coefficient n-octanol/water of the test item was determined to be log Pow = 3.5 at 35 °C by the Reverse Phase High Perfomance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.
- Executive summary:
The study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine the partition coefficient of the test substance. Using the HPLC method partition coefficient Pow was determined in two individual measurements. Finally, a mean value was calculated from these individual log Pow values.The partition coefficient log Pow of the test substance was determined to be log Pow = 3.5 at 35 °C. All validation criteria were fulfilled.
Reference
Description of key information
The partition coefficient n-octanol/water of the test item was determined to be log Pow = 3.5 at 35 °C by the Reverse Phase High Perfomance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.5
- at the temperature of:
- 35 °C
Additional information
The study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine the partition coefficient of the test substance. Using the HPLC method partition coefficient Pow was determined in two individual measurements. Finally, a mean value was calculated from these individual log Pow values.The partition coefficient log Pow of the test substance was determined to be log Pow = 3.5 at 35 °C. All validation criteria were fulfilled.
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