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Density

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Reference
Endpoint:
density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-01-31 – 2017-01-31
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density is calculated from the difference in weight between the full and empty pycnometer and its volume
GLP compliance:
no
Type of method:
pycnometer method
Specific details on test material used for the study:
- Name of the test material: 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-
[9H]xanthene]-3-one
- Molecular formula: C28H30N2O3
- Molecular weight: 442.556 g/mol
- Substance type: Organic
- Smiles: C12(c3c(Oc4c1ccc(c4)N(CC)CC)cc(N(CC)CC)cc3)c1c(cccc1)C(O2)=O
Key result
Type:
pour density
Density:
0.313 g/cm³
Temp.:
26.7 °C
Remarks on result:
other: pressure=978.7 hPa
Key result
Type:
tap density
Density:
0.401 g/cm³
Temp.:
26.7 °C
Remarks on result:
other: pressure-978.7 hPa

By Pour Density and Tapped Density Method:

Method Details

Observations

Guideline

OECD 109

1stReading

2ndReading

Method

Test methods: Pour density and tapped density of

powders” recommended in

The International

Pharmacopoeia, Fourth

Edition, 2014

 

 

Principle of method

Pour Density:It is the ratio of known weight of test item and its volume in graduated

glass cylinder.

Tap Density: It is the

difference between the

volume of test item

measured before & after tapping in the graduated glass cylinder.

 

 

Test temperature (°C)

 

26.7°C

26.7°C

Atmospheric

pressure (in hPa)

 

978.1

979.1

Weight of test

item(m)

 

10.005

10..05

Volume of measuring

cylinder; readability

in g

 

50ml ; 1 ml

50 ml; 1ml

Volume of test item

without tapping (V)

 

31

32

Volume of test item

after tapping ( V1)

After 10 tapping

28

28

 

After 50 tapping

24

26

 

After 100 tapping

24

26

 

After 250 tapping

-

-

 

After 500 tapping

-

-

 

After 750 tapping

-

-

 

CALCULATIONS:

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters

Details

Calculated values

Average

Density

 

 

1st

Calculation

2nd

Calculation

 

Pour Density of test Item

(g/cm³)

m/v

10.005/31

=0.3227

10.005/32

=0.3126

0.3176

Tap density of test Item

(g/cm³)

m/v

10.005/24

=0.4168

10.005/26

=0.3848

0.4008

Conclusions:
The density of substance 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- one (CAS No. 509-34-2)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- oneis was determined to be 0.3176 g/cm³ and 0.4408 g/cm³ at 26.7°C and 978.7 hPa.
Executive summary:

The density of substance 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- one (CAS No. 509-34-2)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- oneis was determined to be 0.3176 g/cm³ and 0.4408 g/cm³ at 26.7°C and 978.7 hPa.

Description of key information

The density of substance 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- one (CAS No. 509-34-2)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- oneis was determined to be 0.3176 g/cm³ and 0.4408 g/cm³ at 26.7°C and 978.7 hPa.

Key value for chemical safety assessment

Relative density at 20C:
0.318

Additional information

The density of substance 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- one (CAS No. 509-34-2)was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus. The mean pour density and tapped density of 3',6'-bis(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3- oneis was determined to be 0.3176 g/cm³ and 0.4408 g/cm³ at 26.7°C and 978.7 hPa.