Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Endpoint summary
Administrative data
Description of key information
Additional information
Bioaccumulation: aquatic
No experimental data for 6-chlorohexyl methacrylate is available to assess the bioaccumulation potential of this substance. The predicted BCF for the substance using BCFBAF v.3.01 (regression-based method) is 197.7 l/kg wet wt using the smile notation ClCCCCCCOC(=O)C(=C)C.
Low potential of bioaccumulation for 6-chlorohexyl methacrylate is expected based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). In fact, as reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004), despite positive and high logKow for short chain methacrylate esters (for example experimental 2-ethylhexyl methacrylate log Kow= 4.95-5.99) they has got a low experimental BCF. In the specific case of 2-ethylhexyl methacrylate (2-EHMA) in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) is reported a BCF =37 in a fish concentration test (Ref. Schäfers, 2006, Fish, Bioconcentration of 2-Ethylhexyl methacrylate according to the OECD-Guideline 305, Report No. MPA-001/4-10, study on behalf of Methacrylate Producers Association, unpublished report).
The predicted low potential of bioaccumulation for 6-chlorohexyl methacrylate is supported by experimental data for the similar substances short chain alkyl methacrylates and in particular by the data for 2-ethylhexyl methacrylate.
Bioaccumulation: terrestrial
No data available.
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