Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Endpoint summary
Administrative data
Description of key information
6-chlorohexyl methacrylate is expected to be of low repeated toxicity for all routes based on its similarity with short chain alkyl methacrylates.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Read-across with similar substances based on information reported SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004)
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data is available for repeated dose toxicity for 6-chlorohexyl methacrylate (6-CHMA). No concern regarding repeated toxicity of 6-CHMA is expected based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
Oral exposure:
No data is available for repeated oral toxicity of 6-chlorohexyl methacrylate (6-CHMA). No concern regarding repeated oral toxicity of 6-CHMA is expected based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for these similar compounds. In particular, experimental data are available for the most similar short chain alkyl methacrylates 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6. In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2 -EHMA a study conducted in 1998 according to OECD 422 (Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test) was reported: 2-EHMA was administered by oral gavage in corn oil to 10 male and 10 female rats at 0, 30, 100, 300, or 1000 mg/kg/day. The NOAEL was 100 mg/kg/day in male rats and 30 mg/kg/day in females, based on organ weight changes in kidney (absolute and relative, without confirmatory histopathology, pituitary gland (relative), and liver (relative) in males and on organ weight changes in both liver (absolute and relative) and kidney (relative only) in females. (Ref. Furuhashi et all, 1998, Combined Repeat Dose and Reproductive /Developmental Toxicity Screening Test of 2-Ethyl Hexyl Methacrylate by Oral Administration in Rats. (English summary), Nihon Bioresearch Inc. Hashima Laboratory,Unpublished report on behalf of Ministry of Health and Welfare, Japan)
Inhalation exposure:
No data is available for repeated inhalation toxicity of 6-chlorohexyl methacrylate (6-CHMA). Some concern regarding repeated inhalation toxicity of 6-CHMA is expected based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for these similar compounds. The mechanism of toxicity has been established as hydrolysis of the parent ester by tissue carboxylesterases to release methacrylic acid (MAA). Based upon the available data a clear trend exists across the short-chain alkyl methacrylate category such that the NOAEC/LOAEC for olfactory nasal lesions increases with increasing ester size. In particular, experimental data are available for the most similar short chain alkyl methacrylates 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6 but this study is of low reliability. In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2 -EHMA a screening study conducted in 1970 no overt (clinical) signs of toxicity were observed in groups of eight rats (4 males and 4 females) exposed to 2-EHMA vapour at concentrations of 60 and 25 ppm (486 and 203 mg/m3) for 6 hr/day, five days per week, over 3 weeks. Gross examination of the major organs revealed no adverse effects, but microscopic examination showed some changes (increased cellularity) to the lungs of the rats exposed to the higher concentration (low reliability study - Ref. Gage , 1970, The subacute inhalation toxicity of 109 industrial chemicals. Brit. J. Industr. Med. 27: 1-18).
Based on the data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for similar compounds and based on low predicted vapour pressure for 6-CHMA (3.01 Pa at T= 25°C) there is no particular concern regarding repeated inhalation toxicity for these substance.
Dermal exposure:
No data is available for repeated dermal toxicity of 6-chlorohexyl methacrylate (6-CHMA) and neither for the similar substance short chain alkyl methacrylates (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). However no concern regarding dermal repeated toxicity of 6-CHMA is based on a general consideration reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004): although no repeat dose dermal studies are available methacrylate esters are generally weakly irritating to the skin and although they tend to be rapidly absorbed and are of low systemic toxicity by acute dermal exposure and upon repeat exposure by other routes. Hence, they are unlikely to represent any greater hazard than that posed by other routes.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), no classification is suggested for repeated toxicity of 6-chlorohexyl methacrylate (6-CHMA) for oral, inhalation and dermal route based on information available for the similar compounds short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
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