Sulfuric acid, C12-14 (even numbered)-alkyl esters, (2-hydroxylpropyl)ammonium salts

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation / corrosion, other

Remarks:

in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

e.g. 24 h occluded exposure, 48 h scoring missing, observation period only 72 h

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium dodecyl sulphate

EC Number:

205-788-1

EC Name:

Sodium dodecyl sulphate

Cas Number:

151-21-3

Molecular formula:

C12H26O4S.Na

IUPAC Name:

sodium dodecyl sulfate

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

No data

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not required

Amount / concentration applied:

0.5 mL

Duration of treatment / exposure:

24 h

Observation period:

72 h

Number of animals:

6

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 24+72 h

Score:

2.2

Max. score:

4

Reversibility:

not fully reversible within: 72 h

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 24+72 h

Score:

1.7

Max. score:

4

Reversibility:

not fully reversible within: 72 h

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria