[No public or meaningful name is available]

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP - Guideline study.

Data source

Reference

Reference Type:

other: inquiry result from ECHA

Title:

Unnamed

Year:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD Guideline No 403, Acute Inhalation Toxicity, May 1981.

GLP compliance:

yes

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-320-1

EC Name:

-

Cas Number:

690-39-1

Molecular formula:

C3H2F6

IUPAC Name:

1,1,1,3,3,3-hexafluoropropane

Details on test material:

Physical form of substance: G
Mass median aerodynamic diameter (for liq.+solid aerosol):
Not applicable for gasses.

Test animals

Species:

other: Rat, Crl:CD BR

Administration / exposure

Vehicle:

other: compressed air

Details on inhalation exposure:

Whole body exposure

Duration of exposure:

4 h

Results and discussion

Effect levels

Dose descriptor:

LC50

Effect level:

> 457 000 ppm

Exp. duration:

4 h

Clinical signs:

other: Signs of toxicity related to dose levels: During the exposure, hyperactivity and then prostration were noted for all animals. At the one-hour post-exposure observation, there were no toxicological significant signs noted. All animals appeared normal on da

Gross pathology:

Effects on organs:
Four animals (1M,3F) had dark red lungs noted at necropsy.
Two females had cysts on the kidneys and one female had an enlarged pituitary gland. There were no other findings at the schedulded necropsy.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU