Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study.

Data source

Reference
Reference Type:
other: inquiry result from ECHA
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Guideline No 403, Acute Inhalation Toxicity, May 1981.
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-320-1
EC Name:
-
Cas Number:
690-39-1
Molecular formula:
C3H2F6
IUPAC Name:
1,1,1,3,3,3-hexafluoropropane
Details on test material:
Physical form of substance: G
Mass median aerodynamic diameter (for liq.+solid aerosol):
Not applicable for gasses.

Test animals

Species:
other: Rat, Crl:CD BR

Administration / exposure

Vehicle:
other: compressed air
Details on inhalation exposure:
Whole body exposure
Duration of exposure:
4 h

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
> 457 000 ppm
Exp. duration:
4 h
Clinical signs:
other: Signs of toxicity related to dose levels: During the exposure, hyperactivity and then prostration were noted for all animals. At the one-hour post-exposure observation, there were no toxicological significant signs noted. All animals appeared normal on da
Gross pathology:
Effects on organs:
Four animals (1M,3F) had dark red lungs noted at necropsy.
Two females had cysts on the kidneys and one female had an enlarged pituitary gland. There were no other findings at the schedulded necropsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU

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