Registration Dossier

Diss Factsheets

Administrative data

Description of key information

The skin irritation/corrosion and eye irritation studies are not required for gases.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation / corrosion
Data waiving:
other justification
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Data waiving:
other justification
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The substance is a gas under atmospheric conditions. The performance of eye and skin irritation studies is not technically feasible and scientifically unjustified. Inhalation of excessive concentrations in air may induce symptoms of hypoxia (headache, nausea, dizziness, loss of consciousness) or cardiac sensitization (irregular pulse or arrhythmia). Direct skin contact at point of release may cause symptoms of frostbite due to evaporative cooling (cold, white, discolored skin that, in severe cases, may exhibit blistering).

Justification for selection of skin irritation / corrosion endpoint:

The performance of skin irritation studies is not technically feasible and scientifically unjustified.

Justification for selection of eye irritation endpoint:

The  performance of eye irritation studies is not technically feasible and scientifically unjustified.

Justification for classification or non-classification

Based on the available information in the dossier, the substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not need to be classified for skin irritation/corrosion and does not need to be classified for serious eye damage/eye irritation when considering the criteria outlined in Annex I of 1272/2008/EC.

Categories Display