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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP compliance , but no test guideline stated.

Data source

Reference Type:
other: inquiry result from ECHA

Materials and methods

Test guideline
according to guideline
other: No test guideline stated in the report.
GLP compliance:
Limit test:

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:

Test animals

other: Rat, Crl : CD BR

Administration / exposure

Route of administration:
other: Filtered, conditioned dilution air.
Details on inhalation exposure:
Method of exposure:
inhalation, whole body exposure
Mass median aerodynamic diameter:
not applicable
Duration of treatment / exposure:
Test duration: 90 days
Frequency of treatment:
Duration of exposure per day: 6 hours
Dosing regime: 5 days/week
No. of animals per sex per dose:
Male: 5 animals at 0 mg/l
Male: 5 animals at 5000 mg/l
Male: 5 animals at 20000 mg/l
Male: 5 animals at 50000 mg/l
Female: 5 animals at 0 mg/l
Female: 5 animals at 5000 mg/l
Female: 5 animals at 20000 mg/l
Female: 5 animals at 50000 mg/l

Results and discussion

Results of examinations

Details on results:
Clinical observations:
The substance had no effect on body weights, no abnormal clinical observations were seen in rats either prior to or following exposures.

The one notable compound-related effect was a diminished response to an alerting stimulus during exposure in the 50000 ppm male and female rats during the first week of the study. A diminished alerting response was noted in some rats primarily during the last two hours of the exposure. The number of rats affected generally decreased with sucessive exposures such that by study day 18, all rats from this group had a normal alerting response. All rats exhibited normal alerting response during the evaluation period immediately after exposure.

Laboratory findings:
No effect on the food consumption or food efficiency was observed.

Effects in organs:
No compound-related effects were detected during the ophthalmological and clinical pathology evaluations. No organ weight differences were seen during necropsy and no histopathologic changes were observed upon microscopic evaluation of tissues. No biologically significant alterations in hepatic peroxisomal á-oxidation activity were seen in any group.

Effect levels

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Dose descriptor:
Effect level:
20 000 mg/L air
Basis for effect level:
other: exposure duration: 6 hours/day NOAEL=2000 ppm (124000 mg/m3)
Dose descriptor:
Effect level:
20 000 mg/L air
Basis for effect level:
other: exposure duration: 6 hours/day NOAEL=2000 ppm (124000 mg/m3)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Classified as: Not classified