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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study.

Data source

Reference
Reference Type:
other: inquiry result from ECHA
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Guidelines No. 471 and 472, May 1983 Ames test
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-320-1
EC Name:
-
Cas Number:
690-39-1
Molecular formula:
C3H2F6
IUPAC Name:
1,1,1,3,3,3-hexafluoropropane

Method

Species / strain
Species / strain / cell type:
bacteria, other: Salmonella typhimurium/ TA100 TA1535 TA98 TA97 Escherichia coli/ WP2uvrA(pKM101)
Metabolic activation system:
With aroclor 1254 rat liver induced S9-mix

Results and discussion

Test results
Species / strain:
bacteria, other: Salmonella typhimurium/ TA100 TA1535 TA98 TA97 Escherichia coli/ WP2uvrA(pKM101)
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Additional information on results:
Observations:
none

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation

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