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EC number: 425-320-1 | CAS number: 690-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Short description of key information:
In accordance with Column 2 of ANNEX VIII of the REACH regulation, screening for reproductive/developmental toxicity study does not need to be conducted as two inhalation pre-natal developmental toxicity studies are available.
Justification for selection of Effect on fertility via inhalation route:
In accordance with Column 2 of ANNEX VIII of the REACH regulation, screening for reproductive/developmental toxicity study does not need to be conducted as two inhalation pre-natal developmental toxicity studies are available.
Effects on developmental toxicity
Description of key information
NOAEC (maternal toxicity) = 5000 ppm = 31,000 mg/m3
NOAEC (embriotoxicity) = 50000 ppm = 310,000 mg/m3
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline No. 414, 1981
- GLP compliance:
- yes
- Limit test:
- no
- Species:
- other: Rat, Crl:CD BR
- Route of administration:
- inhalation
- Vehicle:
- other: Not applicable
- Details on exposure:
- Method of administration or exposure: Whole body exposure
- Frequency of treatment:
- Duration of exposure per day: 6 hours
Dosing regime: 7 days/week - No. of animals per sex per dose:
- Number of dams and doses
25 at 0 mg/kg or mg/l
25 at 5000 mg/kg or mg/l
25 at 20000 mg/kg or mg/l
25 at 50000 mg/kg or mg/l - Details on maternal toxic effects:
- Details on maternal toxic effects:
At the 20000 and 50000 ppm there were significant dose-related decreases in maternal body weight gain over the first two days of inhalation exposures. At 50000 ppm this reduction in weight gain was accompagnied by a significant reduction in maternal food consumption and occasional instances of diminished alerting responses during the inhalation exposures. No evidence of maternal toxicity was detected at 5000 ppm. There was no evidence of developmental toxicity at any level tested. - Dose descriptor:
- NOAEL
- Effect level:
- 5 000 mg/kg bw/day (nominal)
- Basis for effect level:
- other: maternal toxicity
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:
Effects on fetus - Gross:
No compound-related effects on the incidence of early, late or total resorptions were detected. There were no dead fetuses.
No compound-related effects on mean fetal weight were detected. The values for mean fetal weight were comparable across the control and exposure group.
Effects on fetus - Soft tissue:
No compound-related effect on the incidence of fetal malformations and on the incidence of fetal variations was detected.
Effects on fetus - Skeletal:
No compound-related effect on the incidence of fetal malformations and on the incidence of fetal variations was detected. - Dose descriptor:
- NOAEL
- Remarks:
- embriotoxicity
- Effect level:
- 50 000 mg/kg bw/day (nominal)
- Based on:
- not specified
- Basis for effect level:
- other: fetal mortality, weight, malformation and variations.
- Remarks on result:
- other: NOAEL=50000 ppm (310000 mg/m3)
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 310 000 mg/m³
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Information from migrated NONS file, as per inquiry number 06-2120010181-80-0000, permission to refer granted by ECHA.
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In the key pre-natal developmental toxicity study (OECD 414/GLP), 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) was administered to 25 female Crl:CD BR rats via inhalation (whole body inhalation exposure ; 6 hours/day and 7 days/week )at dose levels of 5000, 20000, 50000 ppm . There were significant dose-related decreases in maternal body weight gain over the first two days at the 20000 and 50000 ppm dose levels. At 50000 ppm this reduction in weight gain was accompanied by a significant reduction in maternal food consumption and occasional instances of diminished alerting responses during the inhalation exposures. No evidence of maternal toxicity was detected at 5000 ppm. There were no substance-related effects on developmental toxicity noted at any level tested, including the incidence of early, late or total resorptions, dead foetuses, mean fetal weight, the incidence of fetal malformations and fetal variations in soft tissue and skeletal. Therefore, the established NOAEC of maternal toxicity was 5000 ppm and the NOAEC of embriotoxicity was 50000 ppm.
In the supporting pre-natal developmental toxicity study (OECD 414/GLP),1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) was administered to 20 female rabbits via inhalation ( whole body exposure ; 6 hours/day and 7 days/week ) atdose levels of 5000, 20000, 50000 ppm .). There were no mortalitiesat any dose level and no substance-related effects on maternal body weight, weight gains, food consumption, clinical observations, post-mortem findings and reproductive outcome parameters. There were no substance- related effects on fetal mortality, mean fetal weight, the incidence of fetal malformation and on the incidence of fetal variations in skeletal or soft tissue. Therefore, both of the NOAEL of maternal toxicity and embriotoxicity were 7 mg/l/h/day .
Justification for selection of Effect on developmental toxicity: via oral route:
The study is not required for gases as two inhalation pre-natal developmental toxicity studies are available.
Justification for selection of Effect on developmental toxicity: via inhalation route:
The key study (OECD 414, GLP) was conducted in the rat and indicates a higher level of concern due to adverse maternal effects (NOAEC = 31,000mg/m3). All the acute and repeated dose studies were performed in the rat, so this study was considered the most suitable. Another study (OECD 414, GLP) was conducted in the rabbit and no adverse maternal or developmental effects were noted. The NOAEL values were also provided in non-standard units (7mg/l/g/day).
Justification for selection of Effect on developmental toxicity: via dermal route:
The study is not required for gases as two inhalation pre-natal developmental toxicity studies are available.
Justification for classification or non-classification
Based on the available information in the dossier, 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not need to be classified for reproductive toxicity when the criteria outlined in Annex I of 1272/2008/EC are applied.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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