Registration Dossier
Registration Dossier
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EC number: 425-320-1 | CAS number: 690-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline No. 414, 1981
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 425-320-1
- EC Name:
- -
- Cas Number:
- 690-39-1
- Molecular formula:
- C3H2F6
- IUPAC Name:
- 1,1,1,3,3,3-hexafluoropropane
Constituent 1
Test animals
- Species:
- other: Rat, Crl:CD BR
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: Not applicable
- Details on exposure:
- Method of administration or exposure: Whole body exposure
- Frequency of treatment:
- Duration of exposure per day: 6 hours
Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Number of dams and doses
25 at 0 mg/kg or mg/l
25 at 5000 mg/kg or mg/l
25 at 20000 mg/kg or mg/l
25 at 50000 mg/kg or mg/l
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Details on maternal toxic effects:
At the 20000 and 50000 ppm there were significant dose-related decreases in maternal body weight gain over the first two days of inhalation exposures. At 50000 ppm this reduction in weight gain was accompagnied by a significant reduction in maternal food consumption and occasional instances of diminished alerting responses during the inhalation exposures. No evidence of maternal toxicity was detected at 5000 ppm. There was no evidence of developmental toxicity at any level tested.
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 5 000 mg/kg bw/day (nominal)
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:
Effects on fetus - Gross:
No compound-related effects on the incidence of early, late or total resorptions were detected. There were no dead fetuses.
No compound-related effects on mean fetal weight were detected. The values for mean fetal weight were comparable across the control and exposure group.
Effects on fetus - Soft tissue:
No compound-related effect on the incidence of fetal malformations and on the incidence of fetal variations was detected.
Effects on fetus - Skeletal:
No compound-related effect on the incidence of fetal malformations and on the incidence of fetal variations was detected.
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Remarks:
- embriotoxicity
- Effect level:
- 50 000 mg/kg bw/day (nominal)
- Based on:
- not specified
- Basis for effect level:
- other: fetal mortality, weight, malformation and variations.
- Remarks on result:
- other: NOAEL=50000 ppm (310000 mg/m3)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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