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EC number: 211-923-5 | CAS number: 712-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Nov. 17, 1980 to Dec. 1, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Concentration applied not reported.
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 163.81-5 Vol. 43 No. 163, August 22, 1978
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclohexyl phenyl ketone
- EC Number:
- 211-923-5
- EC Name:
- Cyclohexyl phenyl ketone
- Cas Number:
- 712-50-5
- Molecular formula:
- C13H16O
- IUPAC Name:
- cyclohexyl(phenyl)methanone
- Details on test material:
- - Name of test material (as cited in study report): TK 12828
- Batch No.; 1
- Physical state: paste
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: individually in metal cages
- Diet (e.g. ad libitum): ad libitum standard rabbit food NAFAG No. 814 Gossau, SG
- Water (e.g. ad libitum): ad libitum tap water
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 1
- Photoperiod (hrs dark / hrs light): 10/14
IN-LIFE DATES: From: Novemeber 17, 1980 to Novemeber 23, 1980
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Shaved and one side was abraded.
- Vehicle:
- other: Not clear whether material is inherently a paste or has been formed into a paste
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g of test material applied.
- Duration of treatment / exposure:
- Dressings were removed after 24 hours.
- Observation period:
- 7 days.
- Number of animals:
- 3 males and 3 females.
- Details on study design:
- Entire back and flank of rabbits was shaved before treatment, and then shaven skin on one side of the animal was abraded. Gauze patches of 2.5 X 2 .5cm with 0.5 g of the test material was applied to the abraded and intact skin. The patches were covered with an impermeable material and fastened to the body with adhesive tape. The skin reaction was appraised upon removal and during an observation period of 7 days on the basis of an evaluation scheme.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72 hour
- Score:
- 0.4
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: 0.2 + 1.0 + 0 +0.4 = 1.6/4 = 0.4
- Irritant / corrosive response data:
- Cyclohexylphenylketone was reported to cause minimal irritation when applied to intact and abraded rabbit skin.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified
- Remarks:
- Criteria used for interpretation of results: OECD GHS
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