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Registration Dossier
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EC number: 204-331-3 | CAS number: 119-53-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Mortelmans K et al
- Year:
- 1 986
- Bibliographic source:
- Environ Mutagen 8:1-119 (1986)
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Benzoin
- EC Number:
- 204-331-3
- EC Name:
- Benzoin
- Cas Number:
- 119-53-9
- Molecular formula:
- C14H12O2
- IUPAC Name:
- 2-hydroxy-1,2-diphenylethanone
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat and hamster S9 fraction
- Test concentrations with justification for top dose:
- 33 to 3333 microgram/plate
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Additional information on results:
- Benzoin was found to be negative when tested for mutagenicity using the
Salmonella/microsome preincubation assay, using the standard protocol
approved by the National Toxicology Program (NTP). Benzoin was tested in
as many as 6 Salmonella typhimurium strains (TA1535, TA1537, TA 1538, TA97, TA98,
and TA100) in the presence and absence of rat and hamster liver S-9, at
doses of 0.033, 0.0333, 0.100, 0.333, 0.3333, 0.667, 1.000, and 3.3333
mg/plate. The highest ineffective dose tested in any S. typhimurium strain
was 3.3333 mg/plate. Precipitate was observed in most cultures at the high
dose and also some clearing of the background bacterial lawn was also
seen. [Mortelmans K et al; Environ Mutagen 8:1-119 (1986)] - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
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