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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Final Report of the Safety Assessment of Lithium Stearate, A1 u mi n u m Distearate, Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate, Calcium Stearate, Magnesium Stearate, Potassium Stearate, Sodium Stearate, and Zinc Stearate.
Author:
American College of Toxicology
Year:
1982
Bibliographic source:
International Journal of Toxicology, 1982, vol. 1, no. 2, page-143-177

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: No data
Principles of method if other than guideline:
Acute dermal toxicity study of Aluminum Stearate in guinea pigs
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium tristearate
EC Number:
211-279-5
EC Name:
Aluminium tristearate
Cas Number:
637-12-7
Molecular formula:
C18H36O2.1/3Al
IUPAC Name:
aluminium tristearate
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report):Aluminium tristearate- Molecular formula :C18H36O2.1/3Al- Molecular weight: 877.3995 g/mol- Substance type:Organic- Physical state:Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report):Aluminum Stearate (Aluminum tristearate )- Molecular formula (if other than submission substance):C18H36O2.1/3Al- Molecular weight (if other than submission substance):877.3995 g/mole- Substance type:Organic- Physical state:Solid (powder)

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
24 hrs
Doses:
3000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
Dermal contact with the test material was maintained for 24 hrs.
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
When treated with 3000 mg/kg bw, No mortality were observed in treated Guinea pigs at 3000 mg/kg bw.
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 3000 mg/kg bw when Guinea pigs were treated with aluminum trioctadecanoate orally.
Executive summary:

In a acute dermal toxicity study, Guinea pigs were treated with aluminum trioctadecanoate in the concentration of 3000 mg/kg bw dermally. No mortality were observed in treated Guinea pigs at 3000 mg/kg bw. Therefore, LD50 was considered to be > 3000 mg/kg bw when Guinea pigs were treated with aluminum trioctadecanoate orally.

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