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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from NTRL reports

Data source

Reference
Reference Type:
review article or handbook
Title:
HEALTH AND ENVIRONMENTAL EFFECTS DATA BASE ASSESSMENT OF U.S. ARMY WASTE MATERIAL -Final Report PHASE II REPORT
Author:
J. C. Uhrmacher, P.F. Werschulz, D.O. Schultz and D.O. Weber
Year:
1986
Bibliographic source:
U.S. Army Medical Research and Development Command, submitted on March 4, 1986

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the ocular irritation potential of calcium stearate in mouse
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium distearate
EC Number:
216-472-8
EC Name:
Calcium distearate
Cas Number:
1592-23-0
Molecular formula:
C18H36O2.1/2Ca
IUPAC Name:
calcium dioctadecanoate
Constituent 2
Reference substance name:
Calcium stearate
IUPAC Name:
Calcium stearate
Test material form:
solid
Details on test material:
Name of test material (as cited in study report): Calcium StearateMolecular formula : C36H70CaO4 Molecular weight : 607.04g/mol Smiles notation : C(CCCCCCCCCCC)CCCCCC(=O)[O].C(CCCCCCCCCCC)CCCCCC(=O)[O].[Ca+2]InChl : 1S/2C18H36O2.Ca/c2*123456789101112131415161718(19)20;/h2*217H2,1H3,(H,19,20);/q;;+2/p2Substance Type: OrganicPhysical State: Solid
Specific details on test material used for the study:
Name of test material (as cited in study report): Calcium StearateMolecular formula : C36H70CaO4 Molecular weight : 607.04g/molSmiles notation : C(CCCCCCCCCCC)CCCCCC(=O)[O].C(CCCCCCCCCCC)CCCCCC(=O)[O].[Ca+2]InChl : 1S/2C18H36O2.Ca/c2*123456789101112131415161718(19)20;/h2*217H2,1H3,(H,19,20);/q;;+2/p2Substance Type: OrganicPhysical State: Solid

Test animals / tissue source

Species:
mouse
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irrritating
Conclusions:
Calcium stearate was considered to be not irritating to mouse eyes.
Executive summary:

An ocular irritation study was performed to evaluate the ocular irritation potential of calcium stearate.

The test sample was instilled into mouse eyes and toxic effects were observed (dose and duration not mentioned).

Calcium stearate was considered to be not irritating to mouse eyes.

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