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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985

Materials and methods

Type of study / information:
other: haematotoxicity study
Principles of method if other than guideline:
other: haematotoxicity study in cats
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloro-4-nitrobenzene
EC Number:
210-248-3
EC Name:
1,3-dichloro-4-nitrobenzene
Cas Number:
611-06-3
Molecular formula:
C6H3Cl2NO2
IUPAC Name:
1,3-dichloro-4-nitrobenzene
Details on test material:
purity: 99 %

Results and discussion

Any other information on results incl. tables

Results of the haematological analysis:

             Blood-parameter after         
 Dose (mg/kg)  0 h  3 h  7 h  24 h  30 h  Animal no:  Sex:
 10   Met-hb. (%)  2 3  5422  m
 50   Met-hb. (%)  1  5916  m
 10  HK (%)  6  11  13  10  -  5422  m
 50  HK (%)  3  3  4  5  -  5916  m

m= male

- = not measured

Applicant's summary and conclusion

Executive summary:

In an acute oral gavage toxicity study in cats the animals received 10 and 50 mg/kg bw of test substance in a single dose.

The met-hemoglobin concentration and the number of HEINZ-Innenkörper were not increased after 3, 7, and 24 hours.

Up to 8 hours after application a loss of appetite was observed. No other symptoms were noticed.

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