Registration Dossier
Registration Dossier
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EC number: 210-248-3 | CAS number: 611-06-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Type of study / information:
- other: haematotoxicity study
- Principles of method if other than guideline:
- other: haematotoxicity study in cats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dichloro-4-nitrobenzene
- EC Number:
- 210-248-3
- EC Name:
- 1,3-dichloro-4-nitrobenzene
- Cas Number:
- 611-06-3
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,3-dichloro-4-nitrobenzene
- Details on test material:
- purity: 99 %
Constituent 1
Results and discussion
Any other information on results incl. tables
Results of the haematological analysis:
| Blood-parameter after | ||||||||
| Dose (mg/kg) | 0 h | 3 h | 7 h | 24 h | 30 h | Animal no: | Sex: | |
| 10 | Met-hb. (%) | 2 | 2 | 3 | 1 | - | 5422 | m |
| 50 | Met-hb. (%) | 1 | 2 | 4 | 1 | - | 5916 | m |
| 10 | HK (%) | 6 | 11 | 13 | 10 | - | 5422 | m |
| 50 | HK (%) | 3 | 3 | 4 | 5 | - | 5916 | m |
m= male
- = not measured
Applicant's summary and conclusion
- Executive summary:
In an acute oral gavage toxicity study in cats the animals received 10 and 50 mg/kg bw of test substance in a single dose.
The met-hemoglobin concentration and the number of HEINZ-Innenkörper were not increased after 3, 7, and 24 hours.
Up to 8 hours after application a loss of appetite was observed. No other symptoms were noticed.
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