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EC number: 210-248-3 | CAS number: 611-06-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- other: acute dermal toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-dichloro-4-nitrobenzene
- EC Number:
- 210-248-3
- EC Name:
- 1,3-dichloro-4-nitrobenzene
- Cas Number:
- 611-06-3
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,3-dichloro-4-nitrobenzene
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 0.9 % saline
- Duration of exposure:
- 24 h
- Doses:
- male rats: 2000 mg/kg bw.; female rats: 500, 800, 1000, 1250, 2000 mg/kg bw.
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 921 mg/kg bw
Any other information on results incl. tables
Mortality:
| male rats | female rats | |||
| Dose (mg/kg bw) | absolute | relative (%) | absolute | relative (%) |
| 500 | - | - | 0/5 | 0 |
| 800 | - | - | 2/5 | 40 |
| 1000 | - | - | 2/5 | 40 |
| 1250 | - | - | 5/5 | 100 |
| 2000 | 4/5 | 80 | 5/5 | 100 |
LD50 (mg/kg bw.) 921
Applicant's summary and conclusion
- Executive summary:
In an acute dermal toxicity study in male and female Wistar rats the LD50 was 921 mg/kg bw in female animals. Male rats did not react more sensitive. Doses up to 2000 mg/kg bw. were applied occlusively to the back skin of the rats. Mortality occurred mostly in the night. Symptoms observed were, unspecific symptoms and disturbed course of movement.. In one animal narrowed palpebral fissures were observed. One female animal of the 1250 mg/kg group showed pallidness of skin, drowsiness, diminuated startle reflexes and diminuated breathing frequency.
5 days after treatment all surviving animals were free of symptoms.
No bodyweight abnormalities were observed.
Died animals showed staining at liver, lung and spleen. In the killed animals no abnormalities were observed.
Regarding the LD50 of 921 mg/kg bw the test substance was found to be slightly toxic according to directive 83/467/EWG and therefore classified as R21.
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