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Biodegradation in water

Biodegradability of butyl 12-acetoxyoctadec-9-enoate (CAS no. 140 -04 -5) is predicted using QSAR toolbox version 3.4 with logKow as the primary descriptor (2017). Test substance undergoes 80.33% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical butyl 12-acetoxyoctadec-9-enoate was estimated to be readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound butyl 12-acetoxyoctadec-9-enoate (CAS No.140 -04 -5). If released in to the environment, 24% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of butyl 12-acetoxyoctadec-9-enoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical isnot persistent in waterand the exposure risk to aquatic animals ismoderate to low whereas the half-life period of butyl 12-acetoxyoctadec-9-enoate in sediment is estimated to be 135 days (3240 hrs).However, as the percentage release of test chemical butyl 12-acetoxyoctadec-9-enoate into the sediment is less than 2% (i.e, reported as 1.88%), indicating that the chemical butyl 12-acetoxyoctadec-9-enoate is not persistent in sediment.

Biodegradation in soil

The half-life period of butyl 12-acetoxyoctadec-9-enoate (CAS No. 140 -04 -5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of butyl 12 -acetoxyoctadec-9 -enoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of butyl 12-acetoxyoctadec-9-enoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

2 predicted data for the target compound butyl 12-acetoxyoctadec-9-enoate(CAS no. 140-04-5) and the total 2 weight of evidence studies (from authoritative database) for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:

 

In a predicted data done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemical butyl 12-acetoxyoctadec-9-enoate (CAS no. 140 -04 -5) was estimated. Test substance undergoes 80.33% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical butyl 12-acetoxyoctadec-9-enoate was estimated to be readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound butyl 12-acetoxyoctadec-9-enoate (CAS no. 140 -04 -5) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical butyl 12-acetoxyoctadec-9-enoate  is expected to be readily biodegradable.

 

Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance Bis (2 -ethylhexyl) adipate (CAS no. 103 -23 -1) (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 71% and 85% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, Bis (2 -ethylhexyl) adipate is considered to be readily biodegradable in nature.

 

Another supporting weight of evidence study of biodegradation was conducted for 28 days for evaluating the percentage biodegradability of read across substance butyl octadec-9-enoate (CAS no. 142 -77 -8) (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 63% and 89% by BOD and GC parameter in 14 days. Thus, based on percentage degradation, butyl octadec-9-enoate is considered to be readily biodegradable in nature.

 

On the basis of above results for target chemicalbutyl 12-acetoxyoctadec-9-enoate(from OECD QSAR toolbox version 3.4 and EPI Suite) and for its read across substance (from authoritative database J-CHECK), it can be concluded that the test substance butyl 12-acetoxyoctadec-9-enoatecan be expected to be readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound butyl 12-acetoxyoctadec-9-enoate (CAS No.140 -04 -5). If released in to the environment, 24% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of butyl 12-acetoxyoctadec-9-enoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical isnot persistent in waterand the exposure risk to aquatic animals ismoderate to low whereas the half-life period of butyl 12-acetoxyoctadec-9-enoate in sediment is estimated to be 135 days (3240 hrs).However, as the percentage release of test chemical butyl 12-acetoxyoctadec-9-enoate into the sediment is less than 2% (i.e, reported as 1.88%), indicating that the chemical butyl 12-acetoxyoctadec-9-enoate is not persistent in sediment.

Biodegradation in soil

The half-life period of butyl 12-acetoxyoctadec-9-enoate (CAS No. 140 -04 -5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of butyl 12 -acetoxyoctadec-9 -enoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of butyl 12-acetoxyoctadec-9-enoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance butyl 12-acetoxyoctadec-9-enoate can be considered to be readily biodegradable in nature.