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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Data is from peer- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity studies with insect attractants
Author:
Morton Berozaa, M.N. Inscoea, , P.H. Schwartz Jr.a, M.L. Keplingera, C.W. Mastria
Year:
1975
Bibliographic source:
Toxicology and Applied Pharmacology, Volume 31, Issue 3, March 1975, Pages 421–429

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: No data
Principles of method if other than guideline:
Acute oral toxicity study of Hexalure in rat
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Hexalure
- Molecular formula (if other than submission substance): C18H34O2
- Molecular weight (if other than submission substance): 282.465 g/mole
- Substance type: Organic
- Physical state: colorless liquids
Specific details on test material used for the study:
- Name of test material (as cited in study report): Hexalure
- Molecular formula (if other than submission substance): C18H34O2
- Molecular weight (if other than submission substance): 282.465 g/mole
- Substance type: Organic
- Physical state: colorless liquids
Purity 96 %
- Impurities (identity and concentrations): < 5 % E isomer

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
- Weight at study initiation: 150-240 g
- Fasting period before study: Food was withheld from the rats for 16 hr before dosing.
- Housing: Animals were individually in suspended wire-mesh cages

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No data available
Doses:
Four, five and six dose levels
No. of animals per sex per dose:
2 male, 2 Female
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and gross pathology were examined
Statistics:
LD50 of the test material was calculated by Weil, 1952; Thompson, 1947; Thompson and Weil, 1952

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 34 600 mg/kg bw
Based on:
test mat.
95% CL:
10 250 - 34 600
Remarks on result:
other: No mortality observed
Mortality:
No mortality observed at 34600 mg/kg bw in treated male and female rats.
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was estimated to >34600 mg/kg bw (10250- 34600) when Sprague Dawley male and female rat were treated with Hexalure orally by gavage.
Executive summary:

In a acute oral toxicity study,Sprague Dawley male and female ratwere treated withHexalure infour, five and six dose levelsorally by gavage and observed for 14 days. No mortality observed at 34600 mg/kg bw.Therefore,LD50 was estimated to >34600mg/kg bw (10250- 34600) when Sprague Dawley male and female rat were treated with Hexalure orally by gavage.