Butyl O-acetylricinoleate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Data is from peer- reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Acute toxicity studies with insect attractants

Author:

Morton Berozaa, M.N. Inscoea, , P.H. Schwartz Jr.a, M.L. Keplingera, C.W. Mastria

Year:

1975

Bibliographic source:

Toxicology and Applied Pharmacology, Volume 31, Issue 3, March 1975, Pages 421–429

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: No data

Principles of method if other than guideline:

Acute oral toxicity study of Hexalure in rat

GLP compliance:

not specified

Test type:

other: No data

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Hexalure

Cas Number:

23192-42-9

Molecular formula:

C18H34O2

IUPAC Name:

Hexalure

Details on test material:

- Name of test material (as cited in study report): Hexalure
- Molecular formula (if other than submission substance): C18H34O2
- Molecular weight (if other than submission substance): 282.465 g/mole
- Substance type: Organic
- Physical state: colorless liquids

Specific details on test material used for the study:

- Name of test material (as cited in study report): Hexalure
- Molecular formula (if other than submission substance): C18H34O2
- Molecular weight (if other than submission substance): 282.465 g/mole
- Substance type: Organic
- Physical state: colorless liquids
Purity 96 %
- Impurities (identity and concentrations): < 5 % E isomer

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

- Weight at study initiation: 150-240 g
- Fasting period before study: Food was withheld from the rats for 16 hr before dosing.
- Housing: Animals were individually in suspended wire-mesh cages

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

No data available

Doses:

Four, five and six dose levels

No. of animals per sex per dose:

2 male, 2 Female

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and gross pathology were examined

Statistics:

LD50 of the test material was calculated by Weil, 1952; Thompson, 1947; Thompson and Weil, 1952

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 34 600 mg/kg bw

Based on:

test mat.

95% CL:

10 250 - 34 600

Remarks on result:

other: No mortality observed

Mortality:

No mortality observed at 34600 mg/kg bw in treated male and female rats.

Clinical signs:

No data available

Body weight:

No data available

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

LD50 was estimated to >34600 mg/kg bw (10250- 34600) when Sprague Dawley male and female rat were treated with Hexalure orally by gavage.

Executive summary:

In a acute oral toxicity study,Sprague Dawley male and female ratwere treated withHexalure infour, five and six dose levelsorally by gavage and observed for 14 days. No mortality observed at 34600 mg/kg bw.Therefore,LD50 was estimated to >34600mg/kg bw (10250- 34600) when Sprague Dawley male and female rat were treated with Hexalure orally by gavage.