Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-528-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Feb - 16 Mar 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Niedersächsisches Umweltministerium, Hannover, Germany
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Inoculum of the aqueous phase of non adapted activated sludge
- Details on inoculum:
- - Source of inoculum/activated sludge: Municipal sewage treatment plant, Hildesheim, Germany
- Laboratory culture: no
- Pretreatment: Activated sludge was filtered with folded filter. The first 200 mL of the filtrate were not used. The second filtrate effluent from the domestic waste water is used to initiate inoculation.
- Initial cell/biomass concentration: 10E+4 - 10E+6 Colony Forming Units (CFU)/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 2.5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 7.5 mg/L
- Based on:
- ThOD/L
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Test temperature: 19 - 21 °C
- pH: 7.3 - 7.64 (test item), 7.17 - 7.64 (toxicity control), 6.93 - 7.57 (reference substance), 7.20 - 7.55 (inoculum control)
- pH adjusted: no
- Aeration of dilution water: yes, 1 day before test start
- Continuous darkness: no reported
TEST SYSTEM
- Culturing apparatus: BOD bottles with glass stoppers
- Number of culture flasks/concentration: 2 replicates (10 bottles)
- Measuring equipment: Oximeter, "WTW" oxi 530
- Test performed in closed vessels: yes
SAMPLING
- Sampling frequency: Sampled on day 0, 7, 14, 21 and 28.
- Sampling method: Oxygen contration of duplicates was measured
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 2 replicates (10 bottles)
- Abiotic sterile control: no
- Toxicity control: yes, 2 replicates (10 bottles)
- Other: reference substance: yes, 2 replicates (10 bottles) - Reference substance:
- acetic acid, sodium salt
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- 0% degradation after 28 d, 60% pass level and 10 day window were not met.
- Results with reference substance:
- 77% after 28 d, 60% pass level was reached.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- This study indicates that the substance is not readily biodegradable (0% after 28 d (O2 consumption), OECD 301D).
Table 1: % degradation of the reference substance, test substance and in the toxicity control.
Study day |
Reference substance, mean of 2 replicates [%] |
Test substance, mean of 2 replicates [%] |
Toxicity control, mean of 2 replicates [%] |
0 |
- |
- |
- |
7 |
71 |
0 |
33 |
14 |
69 |
0 |
31 |
21 |
77 |
0 |
36 |
28 |
76 |
0 |
38 |
The toxicity control attained 31% degradation after 14 d indicating that the test substance is not inhibitory to the inoculum (degradation > 25% based on ThOD).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.