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Physical & Chemical properties

Endpoint summary

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Description of key information

Appearance:

On the basis of physical observation ,chemical N-potassium phthalimide was observed to be off white colored crystalline powder in appearance.

Melting point:

The melting point determination of N-potassium phthalimide (CAS No. 1074-82-4) was done following OECD Guideline 102 and according to the metal block capillary method. The test was conducted in replicates and Mean decomposition temperature was determined  to be 370.7- 374.5°C at 972.1hPa.

Boiling point:

The study does not need to be conducted because the substance is a solid which decomposes before boiling

Density:

The density of test item N-potassium phthalimide (CAS No. 1074-82-4)was determined following OECD Guideline 109 and according to theTest methods: Pour density and tappeddensity of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014using bulk density apparatus. The mean pour density and tapped density of test item was determined to be0.4495 g/cm³ and 0.6251 g/cm³at 28°C and 979.2 hPa.

Particle Size Distribution:

The particle size distribution of test item N-potassium phthalimide (CAS No. 1074-82-4 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 150 micron to 10 micron.

Vapour Pressure:

The study does not need to be conducted since the melting point is above 300 deg C. The mean decomposition temperature of N-potassium phthalimide was determined  to be 370.7- 374.5°C at 972.1hPa.Hence this endpoint can be considered for waiver.

Partition Coefficient:

KOWWIN v1.68 was used to estimate the octanol- water partition coefficient of potassium phthalimide.The estimated LogPow of potassium phthalimide was -1.8590.This value suggests that Potassium phthalimide is hydrophilic in nature, which also supported by its solubility in water.

Water Solubility:

The water solubility determination of test item N-potassium phthalimide (CAS No. 1074-82-4) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of N-potassium phthalimide (CAS:1074 -82-4 ) in water was determined to be 1154.942 mg/L at 28°C.

The estimated water solubility of potassium phthalimide at 25 deg C was 1000000 mg/l.

The experimental and estimated values suggests that N-potassium phthalimide is soluble in water.

Surface tension:

In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. The Potassium phthalimide (1074-82-4) is used as a synthetic intermediate. For this use, surface activity is not an important property. Hence this study was considered for waiver.

Flash point:

The flash point determination of potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (CAS No. 1074-82-4)was done following closed cup method using Pensky-Martens flash point apparatus. The test was conducted in replicates and mean flash point was determined to be 174.6°C at 977.8hPa. As data from laboratory has K1 reliability and can be considered as key study for chemical safety assessment.

Autoflammability:

Autoflammability of Potassium 1,3 -dioxo-1,3 -dihydroisoindol-2 -ide from gestis database was determined to be > 400 degree C which indicate that the potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide did not catch fire on being exposed to air at room temperature ,this indicates that

Potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide is not auto-flammable.

Flammability

Potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide does not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded that potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide is not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thus  potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide was considered non-flammable for chemical safety assessment.

Explosivenss:

The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties

Oxidising properties:

The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidising properties and hence, the classification procedure does not need to be applied

pH:

The pH determination of test item potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (CAS No 1074-82-4) was done following OECD guideline 122. pH of 1% w/v solution was measured with the help of pH meter and it was observed to be 9.73at 28 °C. Based on the value the chemical was considered to be basic in nature.

Viscosity:

The study does not need to be conducted because the substance is a solid

Additional information

Appearance:

On the basis of physical observation ,chemical N-potassium phthalimide was observed to be off white colored crystalline powder in appearance.

Other supporting study from authoritative database also suggests that the chemical  Phthalimide, potassium salt was observed to be white to light yellow coloured powder in appearance

Melting point:

The melting point determination of N-potassium phthalimide (CAS No. 1074-82-4) was done following OECD Guideline 102 and according to the metal block capillary method. The test was conducted in replicates and Mean decomposition temperature was determined  to be 370.7- 374.5°C at 972.1hPa.

The supporting study from reliable sources such as handbook and  authoritative database also indicates that there was no melting of the chemical N-potassium phthalimide upto 300 degree C,hence,the melting point was inferred to be >300 degree C.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of decomposition temperature as 370.7 degree C to 374.5 degree C thus considered as key study for the chemical safety assessment.

Boiling point:

The study does not need to be conducted because the substance is a solid which decomposes before boiling.

Density:

The density of test item N-potassium phthalimide (CAS No. 1074-82-4)was determined following OECD Guideline 109 and according to theTest methods: Pour density and tappeddensity of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014using bulk density apparatus. The mean pour density and tapped density of test item was determined to be0.4495 g/cm³ and 0.6251 g/cm³at 28°C and 979.2 hPa.

Other supporting studies from authoritative database also suggests that the density of chemical Phthalimide, potassium salt was reported to be  1.63 g/cm3 at 20 degree C.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of densityas in 0.4495 g/cm3(pour density) and 0.6251 g/cm3(tapped density) at 28 degree C,thus considered as key study for the chemical safety assessment.

Boiling point:

The study does not need to be conducted because the substance is a solid which melts above 300°C.

Particle Size Distribution:

The particle size distribution of test item N-potassium phthalimide (CAS No. 1074-82-4 ) was determined by granulometric analysis with rotap sieve shaker. The particle size distribution was determined to be in the range of 150 micron to 10 micron.

Vapour Pressure:

The study does not need to be conducted since the melting point is above 300 deg C. The mean decomposition temperature of N-potassium phthalimide was determined  to be 370.7- 374.5°C at 972.1hPa.Hence this endpoint can be considered for waiver.

Partition Coefficient:

KOWWIN v1.68 was used to estimate the octanol- water partition coefficient of potassium phthalimide.The estimated LogPow of potassium phthalimide was -1.8590.This value suggests that Potassium phthalimide is hydrophilic in nature, which also supported by its solubility in water.

Water Solubility:

The water solubility determination of test item N-potassium phthalimide (CAS No. 1074-82-4) was done as per the OECD guideline 105 and by spectrophotometric analytical method as per OECD 101. The solubility of N-potassium phthalimide (CAS:1074 -82-4 ) in water was determined to be 1154.942 mg/L at 28°C.

The estimated water solubility of potassium phthalimide at 25 deg C was 1000000 mg/l.

The experimental and estimated values suggests that N-potassium phthalimide is soluble in water.

.

Surface tension:

In accordance with column 2 of Annex VII of the REACH regulation, the study need only be conducted if surface activity is a desired property of the chemical. The Potassium phthalimide (1074-82-4) is used as a synthetic intermediate. For this use, surface activity is not an important property. Hence this study was considered for waiver.

Flash point:

The flash point determination of potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (CAS No. 1074-82-4)was done following closed cup method using Pensky-Martens flash point apparatus. The test was conducted in replicates and mean flash point was determined to be 174.6°C at 977.8hPa. As data from laboratory has K1 reliability and can be considered as key study for chemical safety assessment.

Supported to above key study, from Haz Map database the flash point of the potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (1074-82-4) was determined to be >93.33 degree C.

Based on the above data, it was concluded that, the flash point of the potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (1074-82-4) was determined to be 174.6°C at 977.8hPa.Based on criteria mentioned in CLP regulation the chemical has flash point >than 60 degree C hence the potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (1074-82-4)was considered to be non-flammable.

Autoflammability:

Autoflammability of Potassium 1,3 -dioxo-1,3 -dihydroisoindol-2 -ide from gestis database was determined to be > 400 degree C which indicate that the potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide did not catch fire on being exposed to air at room temperature ,this indicates that Potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide is not auto-flammable.

Flammability

Potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide does not indicate any ignition when the flame of bunsen burner having temperature of approximately 950°C is brought in contact with it. Thus it can be concluded that potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide is not flammable at high temperature. However since such high temperatures are not found under normal circumstances of transportation and use, thus  potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide was considered non-flammable for chemical safety assessment.

Explosivenss:

The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties

Oxidising properties:

The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidising properties and hence, the classification procedure does not need to be applied

pH:

The pH determination of test item potassium 1,3-dioxo-1,3-dihydroisoindol-2-ide (CAS No 1074-82-4) was done following OECD guideline 122. pH of 1% w/v solution was measured with the help of pH meter and it was observed to be 9.73at 28 °C. Based on the value the chemical was considered to be basic in nature.

Viscosity:

The study does not need to be conducted because the substance is a solid

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