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Biodegradation in water

Biodegradability of Potassium phthalimide (CAS no. 1074 -82 -4) is predicted using QSAR toolbox version 3.3 (2017). Test substance undergoes 29.96% degradation by CO2 evolution parameter in 28 days. Thus, based on percentage degradation, the test chemical Potassium phthalimide was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Potassium phthalimide (CAS No. 1074 -82 -4). If released in to the environment, 19.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Potassium phthalimide in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Potassium phthalimide in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.118%), indicates that Potassium phthalimide is not persistent in nature.   

Biodegradation in soil

The half-life period of Potassium phthalimide (CAS No. 1074 -82 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.8% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Potassium phthalimide in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Potassium phthalimide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

In different studies, Potassium phthalimide (CAS No. 1074 -82 -4) has been investigated for potential for biodegradation to a greater or lesser extent. These include 2 predicted data for the target compound Potassium phthalimide and the 1 study (from authoritative database) for its closest read across substance with logKow as the primary descriptor.

 

In a predicted data done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical Potassium phthalimide (CAS no. 1074 -82 -4) was estimated. Test substance undergoes 29.96% degradation by CO2 evolution parameter in 28 days. Thus, based on percentage degradation, the test chemical Potassium phthalimide was estimated to be not readily biodegradable in water.

 

Another prediction was done using the Estimation Programs Interface Suite (EPI suite, 2017) for estimating the biodegradation potential of the test compound Potassium phthalimide (CAS no. 1074 -82 -4)in the presence of mixed populations of environmental microorganisms.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that Potassium phthalimide is expected to be not readily biodegradable.

 

In an additional supporting weight of evidence studyof read acrosssubstance1,2,3,6-Tetrahydrophthalimide (CAS no. 85-40-5) from authoritative database (J-CHECK, 2016), biodegradation experiment was conducted for 28 days forevaluating the percentage biodegradability of read across substance 1,2,3,6-Tetrahydrophthalimide. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance1,2,3,6-Tetrahydrophthalimidewas determined to be0, 3 and 8% degradation by BOD, TOC removal and HPLC parameter in 28 days, respectively.Thus, based on percentage degradation,1,2,3,6-Tetrahydrophthalimidewas considered to be not readily biodegradable in nature.

 

On the basis of above results for target chemical Potassium phthalimide (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK), it can be concluded that the test substance Potassium phthalimide can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Potassium phthalimide (CAS No. 1074 -82 -4). If released in to the environment, 19.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Potassium phthalimide in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Potassium phthalimide in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.118%), indicates that Potassium phthalimide is not persistent in nature.   

Biodegradation in soil

The half-life period of Potassium phthalimide (CAS No. 1074 -82 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.8% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Potassium phthalimide in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Potassium phthalimide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance Potassium phthalimide can be considered to be not readily biodegradable in nature.