Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study is comparable with the OECD Guideline 403 with acceptable restrictions mostly due to reduced documentation and no GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Method: other: BASF-Test
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhex-2-enal
EC Number:
211-448-3
EC Name:
2-ethylhex-2-enal
Cas Number:
645-62-5
Molecular formula:
C8H14O
IUPAC Name:
2-ethylhex-2-enal
Details on test material:
- Name of test material (as cited in study report): 2-Ethyl-hexen-2-al-1
- Physical state: liquid
- Analytical purity: ca 97 %

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Duration of exposure:
8 h
Concentrations:
3.98 mg/l
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: at the beginning
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
4 mg/L air (nominal)
Exp. duration:
8 h
Mortality:
No mortality was observed
Clinical signs:
other: nose, bloody smeared; dyspnea; gasping breathing;
Gross pathology:
no findings

Any other information on results incl. tables

0/12 animals died within 8 hours after exposure to 3.98 mg/l

Applicant's summary and conclusion