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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets scientific standards with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
Skin irritation was tested using an internal method (BASF-test)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhex-2-enal
EC Number:
211-448-3
EC Name:
2-ethylhex-2-enal
Cas Number:
645-62-5
Molecular formula:
C8H14O
IUPAC Name:
2-ethylhex-2-enal
Details on test material:
- Name of test material (as cited in study report): 2-Ethyl-hexen-2-al-1
- Physical state: liquid

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.96 - 3.1 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
An application site of 2.5 x 2.5 cm was covered.
Duration of treatment / exposure:
1. Experiment: 1, 5, 15 minutes
2. Experiment: 20 hours
Observation period:
up to 8 days
Number of animals:
2

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
2
Irritant / corrosive response data:
severe irritant; corrosive properties cannot be fully excluded

Any other information on results incl. tables

Exposure time

Results after 24 hours

Results after 8 days

1 min

Redness 2

Redness 1

5 min

Redness 2

Redness 1/ Scurf 2

15 min

Redness  2

Necrosis1 / Scurf 2

20 hours

Necrosis 1/ Redness 2 / Oedema 1

Necrosis 2

Applicant's summary and conclusion