Reaction mass of disodium carbonate and disodium sulfate and sodium chloride

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1954

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1954

Report date:

1954

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

None

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium chloride

EC Number:

231-598-3

EC Name:

Sodium chloride

Cas Number:

7647-14-5

Molecular formula:

ClNa

IUPAC Name:

sodium chloride

Details on test material:

- Name of test material (as cited in study report): Sodium Chloride
- Common name: Table salt
- Physical state: White solid granules
- Soluble: Water

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

No data

Test system

Vehicle:

water

Remarks:

for 5%, 10%, 20% and 50 % NaCl solution

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Concentration (if solution): 5%, 10%, 20% and 50 % and 100% NaCl

Duration of treatment / exposure:

No data

Observation period (in vivo):

No data

Number of animals or in vitro replicates:

No data

Details on study design:

Please see the table below.

Results and discussion

In vivo

Results

Remarks on result:

other: Based on observations, the substance can be considered as irritating for eyes. No scores are available on this study.

Remarks:

The following responses were observed: pain, conjunctival irritation and corneal injury.

Irritant / corrosive response data:

Sodium chloride and its strong solution (50%) present a slight hazard from contact with the eye. Pain and conjunctival inflammation may persist for several days. Transient corneal injury may occur, but is expected to heal completely within a few days. Solution (20% or less) are not likely to cause injury to the eye. Contact is but very slightly painful and irritating.

Other effects:

None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

Sodium chloride presents a hazard from eye contact, both in the solid form and at the 50% concentration in water. Lower concentration (20% and 10%) cause slight pain and irritation which heals readily. Solutions of 5% cause only a trace of pain and no irritation.

Executive summary:

Sodium chloride or its concentrated solutions (50% or greater) caused pain and conjunctival inflammation which persisted for several days. Transient corneal injury occurred which resolved completely within a few days. Solutions of 20% or less caused slight pain and irritation which healed readily. Solutions of 5% or less caused only a trace of pain and no irritation.

Pure substance and 50% in solution is considered to induce eye irritation. Solution of 20% or less induces only slight eye irritation.

As a comparative reference, normal seawater is ~3.3% salt solution.

Only pure substance and solution of 50% are considered to be irritating to eyes and are classified Eye. irrit. Cat. 2, H319 according to EU GHS criteria.