Registration Dossier
Registration Dossier
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EC number: 215-158-8 | CAS number: 1308-14-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 21 Days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Peer reviewed publication
- Test organisms (species):
- Daphnia magna
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- 2 mg/L
- Conc. based on:
- element
- Remarks:
- chromium
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 0.6 mg/L
- Conc. based on:
- element
- Remarks:
- chromium
- Basis for effect:
- reproduction
- Executive summary:
The toxicities of various metals to Daphnia magna were evaluated on the basis of a 48-hr 50% lethal concentration (LC50) a 3-week LC50, and a 16% decrease in the number of young born (reproductive impairment). The 3-week 16% reproductive impairment concentrations (in micrograms per liter) for the metal ions tested were: Na(I), 680,000; Ca(II), 116,000; Mg(II), 82,000; K(I), 53,000; Sr(II), 42,000; Ba(II), 5800; Fe(III), 4380; Mn(II), 4100; As(V), 520; Sn(II), 350; Cr(III), 330; Al(III), 320; Zn(II), 70; Au(III), 60; Ni(II), 30; Pb(II), 30; Cu(II), 22; Pt(IV), 14; Co(II), 10; Hg(II), 3.4; and Cd(II), 0.17. At metal concentrations permitting survival but impairing reproduction, daphnids weighed less than control animals. Amounts of total protein and glutamic oxalacetic transaminase activity varied with the different metals. The negative logarithm of the solubility product constant (pKsp) of the metal sulfides, electronegativity, and the logarithm of the equilibrium constant (log Keg) of the metal–ATP complex were positively correlated with toxicity toD. magna. Other physicochemical properties were considered, but no additional correlations were found.
Reference
Description of key information
The 21 day NOEC (reproduction) for chromium 3+ was 0.7 mg/l and 24 hr EC50 (immobilisation) was 22 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.4 mg/L
Additional information
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