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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
21 Days
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Peer reviewed publication
Test organisms (species):
Daphnia magna
Duration:
21 d
Dose descriptor:
LC50
Effect conc.:
2 mg/L
Conc. based on:
element
Remarks:
chromium
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
0.6 mg/L
Conc. based on:
element
Remarks:
chromium
Basis for effect:
reproduction
Executive summary:

The toxicities of various metals to Daphnia magna were evaluated on the basis of a 48-hr 50% lethal concentration (LC50) a 3-week LC50, and a 16% decrease in the number of young born (reproductive impairment). The 3-week 16% reproductive impairment concentrations (in micrograms per liter) for the metal ions tested were: Na(I), 680,000; Ca(II), 116,000; Mg(II), 82,000; K(I), 53,000; Sr(II), 42,000; Ba(II), 5800; Fe(III), 4380; Mn(II), 4100; As(V), 520; Sn(II), 350; Cr(III), 330; Al(III), 320; Zn(II), 70; Au(III), 60; Ni(II), 30; Pb(II), 30; Cu(II), 22; Pt(IV), 14; Co(II), 10; Hg(II), 3.4; and Cd(II), 0.17. At metal concentrations permitting survival but impairing reproduction, daphnids weighed less than control animals. Amounts of total protein and glutamic oxalacetic transaminase activity varied with the different metals. The negative logarithm of the solubility product constant (pKsp) of the metal sulfides, electronegativity, and the logarithm of the equilibrium constant (log Keg) of the metal–ATP complex were positively correlated with toxicity toD. magna. Other physicochemical properties were considered, but no additional correlations were found.

Description of key information

The 21 day NOEC (reproduction) for chromium 3+ was 0.7 mg/l and 24 hr EC50 (immobilisation) was 22 mg/l.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1.4 mg/L

Additional information

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