Registration Dossier
Registration Dossier
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EC number: 454-190-9 | CAS number: 324763-51-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
For the purpose of assessing the toxicokinetic behaviour,
the high water solubility (814 g/l)
and the low n-octanol/water partition coefficient (-1.17)
of the test substance are relevant.
These properties will enable only a limited penetration of
the test substance through membranes. The potential for
bioaccumulation is therefore considered to be low.
A few and low-sized systemic effects detected in the
repeated oral dose study might indicate an absorption of the
test substance in the gastrointestinal tract and a
distribution in the body.
The low lethal doses in the acute oral and the acute dermal
toxicity studies do not give a hint on the importance of
absorption barriers.
No relevant differences occurred in the two mutagenicity
studies with and without the addition of a metabolising
system. Therefore no indication of the importance of the
metabolism of the test substance was obtained from these
studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
