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Diss Factsheets
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EC number: 200-888-1 | CAS number: 75-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
- Principles of method if other than guideline:
- BASF Test
- GLP compliance:
- no
Test material
- Reference substance name:
- tert-butylamine
- EC Number:
- 200-888-1
- EC Name:
- tert-butylamine
- Cas Number:
- 75-64-9
- Molecular formula:
- C4H11N
- IUPAC Name:
- 2-methylpropan-2-amine
- Details on test material:
- - Name of test material (as cited in study report): tert-butylamine
- no further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.28 and2.25 kg
- Housing: individual
- Diet ad libitum
- Water ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: concurrent phys. saline
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 ml
- Concentration (if solution): undiluted
- Duration of treatment / exposure:
- not applicable, test substance remained in the eye and was not washed out
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM: The original scoring system was converted into Draize scores
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: severe eye damage, endpoints erythrema and chemosis therefore not scored
Any other information on results incl. tables
Readings |
Animal |
Cornea |
Iris |
Conjunctiva |
Additional findings |
|||
op |
ar |
red |
ch |
di |
||||
10 min |
1 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva |
2 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva |
|
1 h |
1 |
- |
- |
- |
- |
- |
- |
chemical burns of conjunctiva (brown-colored appearance), milky opacity |
2 |
- |
- |
- |
- |
- |
- |
chemical burns of conjunctiva (brown-colored appearance), milky opacity |
|
24 h |
1 |
|
|
|
|
|
|
chemical burns of eye ball, nictitating membrane and conjunctiva |
2 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva |
|
48 h |
1 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva, ulceration, chemosis of the surrounding tissue |
2 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva, ulceration |
|
72 h |
1 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva, ulceration, chemosis of the surrounding tissue |
2 |
- |
- |
- |
- |
- |
- |
chemical burns of eye ball, nictitating membrane and conjunctiva, ulceration |
|
7 d |
1 |
- |
- |
- |
- |
- |
- |
necrosis on eyelids, blepharophimosis, chemosis not assessable; eyes clotted with pus |
2 |
- |
- |
- |
- |
- |
- |
necrosis and swelling of eyelids, pus secretion, corneal lesions with loss of lens |
- endpoint not scored because of severe damage of the eye
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.