Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-357-1 | CAS number: 16245-77-5
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Based on the study performed according to OECD guideline 301D the test chemical Benzene-1,4-diammonium sulphate (CAS No.16245-77-5) undergoes 75% biodegradation after 42 days in the test condition. Thus, the test chemical was considered to be inherently biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI) Suite (2017) prediction model was run to predict the half-life in water and sediment for the test compound Benzene-1,4 -diammonium sulphate (CAS No. 16245 -77 -5). If released in to the environment, 24.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Benzene-1,4 -diammonium sulphate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Benzene-1,4-diammonium sulphate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical Benzene-1,4-diammonium sulphate into the sediment is less than 1% (i.e, reported as 0.0748%), indicates that Benzene-1,4-diammonium sulphate is not persistent in sediment.
Biodegradation in soil
The half-life period of Benzene-1,4-diammonium sulphate (CAS No. 16245 -77 -5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 75.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Benzene-1,4-diammonium sulphate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Benzene-1,4 -diammonium sulphate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water:
Experimental studies according OECD guildeline were performed for target chemical Benzene-1,4-diammonium sulphate (CAS No.16245-77-5) and its structurally similar read across chemical for biodegradation in water endpoints and their results are summarized below.
The first study was experimental study in this study the 42 -days Closed Bottle test following the OECD guideline 301 D was performed to determine the ready biodegradability of the test item Benzene-1,4-diammonium sulphate (CAS No.16245-77-5). The study was performed at a temperature of 20°C. The test system included control, test item and reference item. Polyseed were used for this study. 1 polyseed capsule were added in 500 ml D.I water and then stirred for 1 hour for proper mixing and functioning of inoculum. This gave the bacterial count as 107to 108CFU/ ml. At the regular interval microbial plating was also performed on agar to confirm the vitality and CFU count of microorganism. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml/l. OECD mineral medium was used for the study. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % degradation was calculated using the values of BOD and ThOD for test item and reference item. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was determined to be 75.3%. Degradation of Sodium Benzoate exceeds 46.38 % on 7 days & 61.44 % on 14th day. The activity of the inoculum is thus verified and the test can be considered as valid. The BOD42 value of test chemical Benzene-1,4-diammonium sulphate was observed to be 0.75 mgO2/mg. ThOD was calculated as 1 mgO2/mg. Accordingly, the % degradation of the test item after 42 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 75%. Based on the results, the test item, under the test conditions, was considered to be inherently biodegradable in nature.
Next study was also experimental study in this study the ready biodegradability of the test substance was determined in the Closed Bottle test performed according to slightly modified OECD guidelines. The test was prolonged because the pass level was not reached at day 28 and the test substance was used as received from Akzo Nobel Fibres, Amhem. Validity of the test was confirmed by endogenous respiration of 1.5 mg/L, oxygen concentrations > 0.5 mg/L in all bottles during the test period, and less than 20% differences between replicates. The test substance caused no reduction in the endogenous respiration. Therefore, the test substance is considered to be non-inhibitory to the inoculum. The test substance was biodegraded approximately 30% at day 28 in the Closed Bottle test. After 84 d, the biodegradation percentage did not increase. Therefore, the test substance is inherently biodegradable. The biodegradation percentages found were comparable in the presence and absence of silica gel, suggesting that the test substance is not toxic to activated sludge at the tested concentration.
By considering results of both the studies mentioned above it is concluded that test chemical Benzene-1,4-diammonium sulphate (CAS No.16245-77-5) is inherently biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI) Suite (2017) prediction model was run to predict the half-life in water and sediment for the test compound Benzene-1,4 -diammonium sulphate (CAS No. 16245 -77 -5). If released in to the environment, 24.5% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Benzene-1,4 -diammonium sulphate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Benzene-1,4-diammonium sulphate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical Benzene-1,4-diammonium sulphate into the sediment is less than 1% (i.e, reported as 0.0748%), indicates that Benzene-1,4-diammonium sulphate is not persistent in sediment.
Biodegradation in soil
The half-life period of Benzene-1,4-diammonium sulphate (CAS No. 16245 -77 -5) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 75.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Benzene-1,4-diammonium sulphate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Benzene-1,4 -diammonium sulphate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance Benzene-1,4-diammonium sulphate can be considered to be inherently biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
