Registration Dossier

Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-piperidinecarboxylic acid hydrochloride
EC Number:
611-901-9
Cas Number:
5984-56-5
Molecular formula:
C6H11NO2.HCl
IUPAC Name:
4-piperidinecarboxylic acid hydrochloride
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study reports): JNJ-150098-AAC (T001310)
- Physical state: solid
- Appearance white powder
Specific details on test material used for the study:
No data

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
1.9 other: g/100 mL solution
Temp.:
20 °C
Medium:
ethanol
Solubility:
0.26 other: g/100 mL solution
Temp.:
20 °C
Medium:
isopropanol
Solubility:
0.05 other: g/100 mL solution
Temp.:
20 °C
Medium:
other: dichloromethane
Solubility:
0.01 other: g/100 mL solution
Temp.:
20 °C
Medium:
other: 2-propanone
Solubility:
< 0.01 other: g/100 mL solution
Temp.:
20 °C
Medium:
other: 1,1'-oxybisethane
Solubility:
< 0.01 other: g/100 mL solution
Temp.:
20 °C
Medium:
other: methylbenzene
Solubility:
< 0.01 other: g/100 mL solution
Temp.:
20 °C
Medium:
dimethylformamide
Solubility:
0.32 other: g/100 mL solution
Temp.:
20 °C
Details on results:
no data

Any other information on results incl. tables

Table 1 Solubility of the T001310 at room temperature

 Solvent  Concentration in g/100 mL solution
 4 -methyl-2-pentanone  < 0.01
 2 -butanone < 0.01
 2,2'-oxybispropane  < 0.01

Applicant's summary and conclusion

Executive summary:

Not applicable