Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 611-901-9 | CAS number: 5984-56-5
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 August - 22 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 4-piperidinecarboxylic acid hydrochloride
- EC Number:
- 611-901-9
- Cas Number:
- 5984-56-5
- Molecular formula:
- C6H11NO2.HCl
- IUPAC Name:
- 4-piperidinecarboxylic acid hydrochloride
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-150098-AAC (T001310)
- Physical state: solid
- Appearance white powder
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: I14KB4913
- Analytical purity: 97.4% (base titration)
- Expiration date: 23 November 2020 (retest date)
- Storage condition: at room temperature
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 298.2 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Remarks:
- Reaction and/or decomposition was observed directly after melting. A dark brown molten residue remained after the preliminary test and the main tests (original colour: white).
Any other information on results incl. tables
Preliminary test
From the TGA curve it could be derived that the weight of the sample decreased significantly starting at 300°C. At 357°C the sample weight has decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: white) and a brown residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item.
Main tests
The DSC curve from the first experiment with a heating rate of 20°C/min showed a small endothermic peak between 150°C and 200°C. The extrapolated onset temperature of the peak was 184.08°C. According to information supplied by the sponsor, the effect was most likely obtained due to a solid-solid or phase transformation. A second endothermic peak was observed starting at 250°C. The extrapolated onset temperature of the peak was 298.20°C. This effect was most likely obtained due to melting followed by reaction and/or decomposition of the test item. After the experiment, a brown molten residue remained. To investigate the endothermic peak between 150°C and 200°C, a repeated heating cycle was applied in Experiment 2. The extrapolated onset temperature of the peak was 184.29°C. After the experiment the material seemed unchanged. Experiment 3 was performed to investigate the endothermic peak starting at 250°C. The extrapolated onset temperature of the first peak was 184.31°C and of the second peak 298.26°C. After the experiment, a white molten residue remained in the sample container. The result demonstrated that the second endothermic effect was due to melting of the test item.
To further investigate the endothermic peak between 150°C and 200°C, a repeated heating cycle was applied in Experiment 4. The extrapolated onset temperature of the peak was 183.97°C. This peak can be related to a solid-solid or phase transformation.
The melting temperature of T001310 was determined as the average melting temperature obtained from Experiment 1 and Experiment 3 and equals 298.2°C (571.4K).
According to the sponsor, the second endothermic effect observed in Experiment 1 (184.08°C), Experiment 2 (184.29°C), Experiment 3 (184.31°C) and Experiment 4 (183.97°C), derives from a
solid-solid or phase transformation.
Applicant's summary and conclusion
- Conclusions:
- JNJ-150098-AAC (T001310) was determined to be 298.2°C (571.4K) by using DSC.
According to the sponsor, a second endothermic effect observed at 184.2°C (457.3K), derives from a solid-solid or phase transformation.
Reaction and/or decomposition of the test item was observed directly after melting.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
