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EC number: 619-383-6 | CAS number: 98967-40-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 10 January 1991 to 7 June 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 162-1
- Principles of method if other than guideline:
- The objective is to test whether DE-498 has a shorter half-life at high soil pH and longer half-life in soils with high organic matter content.
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- EC Number:
- 619-383-6
- Cas Number:
- 98967-40-9
- Molecular formula:
- C12H9F2N5O2S
- IUPAC Name:
- N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- Reference substance name:
- N-(2',6'-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- IUPAC Name:
- N-(2',6'-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- Details on test material:
- - Name of test material (as cited in study report):DE-498
- Radiochemical purity (if radiolabelling):96%
- Name of test material (as cited in study report): DE-498
- Analytical purity: 99.6%
- Lot/batch No.: AGR240043
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
In Appling Course and Commerce soils, DE-498 degraded with pseudo-first order half lives, based on initial rate data, of 27 and 42 days, respectively. No accumulation of metabolites above 10% of the applied radioactivity were observed, and DE-498 became increasingly bound to soil organic matter with time. It is unlikely that the material contained in the bound fraction of the soil (i.e., extractable only by caustic) is available to the environment for plant uptake or other processes.
Applicant's summary and conclusion
- Conclusions:
- It is unlikely that the DE-498 contained in the bound fraction of the soil (i.e., extractable only by caustic) is available to the environment for plant uptake or other processes. The parent material should be the only aerobic analyte of concern for future field studies.
- Executive summary:
The degradation of DE-498, uniformly 14C-labeled in the aniline portion of the molecule, was studied in Appling Coarse sandy clay loam and Commerce silt loam soils. The chemical was applied at 0.07 ppm, corresponding to the maximum field application rate of 79 grams per hectare, as well as the concentration found in field dissipation studies. Under aerobic conditions at 25 degrees C, DE-498 degraded with apparent first order half lives, based on initial rate data, of 27 and 42 days, in the Appling and Commerce soils, respectively. These results are comparable to data obtained with DE-498 radiolabeled on the pyrimidine portion of the molecule. No accumulation of metabolites above 10% of applied DE-498 was observed and DE-498 became increasingly bound to soil organic matter with time. Thus, the parent should be the only aerobic analyte of concern for future field studies. Overall 14C accountability averaged greater than 94% of the applied activity.
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