Tetrabutylammonium iodide

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

Data is from peer reviewed journal

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

Toxicity to V. fischeri was measured as inhibition of bioluminescence using Microtoxs M500 Rapid Toxicity Testing System equipment and consumables.The assay was carried out in accordance with the 90% basic test for pure compounds protocol, as described in the Microtox user’s manual.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): N,N,N-tributylbutan-1-aminium iodide
- Molecular formula (if other than submission substance): C16H36N.I
- Molecular weight (if other than submission substance): 369.367 g/mol
- Smiles notation (if other than submission substance): [N+](CCCC)(CCCC)(CCCC)CCCC.[IH-]
- InChI: 1S/C16H36N.HI/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1
- Substance type: Organic
- Physical state: Solid

Analytical monitoring:

yes

Vehicle:

not specified

Test organisms (species):

Vibrio fisheri

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

15 min

Details on test conditions:

TEST SYSTEM
- No. of vessels per concentration (replicates):triplicates

Reference substance (positive control):

not specified

Key result

Duration:

15 min

Dose descriptor:

EC50

Effect conc.:

284 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Details on results:

Results of the Student–Newman–Keuls post-hoc statistical test for pairwise comparison of EC50 (mmol L/1).

Reported statistics and error estimates:

The differences tested by ANOVA are highly significant (P o 0.001), moreover, the post-hoc test.

Validity criteria fulfilled:

not specified

Conclusions:

Vibrio fischeri in a 15 min inhibition of bioluminescence test the 50% effect concentrations (EC50) of the ammonium salts TBAI was observed to be 284 mg/l with 95% confidence limit (241–336)

Executive summary:

Toxicity to V. fischeri was measured as inhibition of bioluminescence using Microtoxs M500 Rapid Toxicity Testing System equipment and consumables.The assay was carried out in accordance with the 90% basic test for pure compounds protocol, as described in the Microtox user’s manual.

The EC50 values of the tested ammonium salts for V. fischeri range from 1.3 to 284 mg L1. The differences tested by ANOVA are highly significant (P o 0.001).

In experiment the 50% effect concentrations (EC50) of the ammonium salts TBAI to Vibrio fischeri in a 15 min inhibition of bioluminescence test was observed to be 284 mg/l with 95% confidence limit (241–336).

Description of key information

Vibrio fischeri in a 15 min inhibition of bioluminescence test the 50% effect concentrations (EC50) of the ammonium salts TBAI was observed to be 284 mg/l with 95% confidence limit (241–336)

Key value for chemical safety assessment

EC50 for microorganisms:

284 mg/L

Additional information

Toxicity to V. fischeri was measured as inhibition of bioluminescence using Microtoxs M500 Rapid Toxicity Testing System equipment and consumables.The assay was carried out in accordance with the 90% basic test for pure compounds protocol, as described in the Microtox user’s manual.

The EC50 values of the tested ammonium salts for V. fischeri range from 1.3 to 284 mg L1. The differences tested by ANOVA are highly significant (P o 0.001).

In experiment the 50% effect concentrations (EC50) of the ammonium salts TBAI to Vibrio fischeri in a 15 min inhibition of bioluminescence test was observed to be 284 mg/l with 95% confidence limit (241–336).