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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report, CAS no: 102-82-9(Tributylamine)
Author:
Benson A
Year:
2014
Bibliographic source:
SIDS Initial Assessment Report, CoCAM 6, 30 - 03 October, 2014.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Principles of method if other than guideline:
Skin sensitization study of Tributylamine was performed in guinea pig by Buehler test.
GLP compliance:
not specified
Type of study:
Buehler test
Justification for non-LLNA method:
Not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-dibutylbutan-1-amine
Cas Number:
102-82-9
Molecular formula:
C12H27N
IUPAC Name:
N,N-dibutylbutan-1-amine
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Tributylamine
- Molecular formula: C12H27N
- Molecular weight: 185.352 g/mol
- Smiles notation: N(CCCC)(CCCC)CCCC
- InChl: 1S/C12H27N/c1-4-7-10-13(11-8-5-2)12-9-6-3/h4-12H2,1-3H3
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
-Name of test material (as cited in study report): Tributylamine
- Molecular formula: C12H27N
- Molecular weight: 185.352g/mole
- Substance type: organic

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
epicutaneous, occlusive
Vehicle:
not specified
Challenge
No.:
#1
Route:
other: No data available
Vehicle:
not specified
Concentration / amount:
No data available
No. of animals per dose:
No data available
Details on study design:
No data available
Challenge controls:
No data available
Positive control substance(s):
no

Study design: in vivo (LLNA)

Statistics:
No data available

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
No data available
No. with + reactions:
0
Clinical observations:
NO sensitization reaction observed after challenge application
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

No indication of skin sensitization.

Applicant's summary and conclusion

Interpretation of results:
other: No skin sensitization reactions were observed.
Conclusions:
Skin sensitization study of Tributylamine was performed in guinea pig by Buehler test . The test was considered to be not sensitizing.
Executive summary:

Skin sensitization study of Tributylamine (102 -82 -9) was performed in guinea pig by Buehler test .The test showed no sign of skin sensitization in guinea pig. Therefore

Tributylamine (102 -82 -9) was considered to be not sensitizing in guinea pig .