Registration Dossier
Registration Dossier
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EC number: 208-336-1 | CAS number: 522-75-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of given test chemical in mouse.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-(Aminophenylmethylene)benzo(b)thiophene-3-one
- Cas Number:
- 77946-49-7
- IUPAC Name:
- 2-(Aminophenylmethylene)benzo(b)thiophene-3-one
- Details on test material:
- - IUPAC Name: 2-(Aminophenylmethylene)benzo(b)thiophene-3-one
- Common Name: AF-CX 921XX
- InChI: 1S/C15H11NOS/c16-13(10-6-2-1-3-7-10)15-14(17)11-8-4-5-9-12(11)18-15/h1-9H,16H2/b15-13+
- Smiles: c12c(C(\C(S1)=C(\c1ccccc1)N)=O)cccc2
- Molecular weight :253.324g/mole
- Substance type:Organic
- Physical state:solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2400 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral toxicity dose (LD50) value was considered to be 2400 mg/kg bw, when mice were treated with given test chemical via oral route.
- Executive summary:
The acute oral toxicity study was conducted by using test chemical in mice at the concentration of 2400 mg/kg bw. 50% mortality was observed at 2400 mg/kg bw. Hence, LD50 value was considered to be 2400 mg/kg bw, when mice were treated with given test chemical via oral route.
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