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Density

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Reference
Endpoint:
density
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-03-10 – 2017-03-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental result performed using standard methods of analysis
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density is calculated from the difference in weight between the full and empty pycnometer and its volume
GLP compliance:
no
Type of method:
pycnometer method
Specific details on test material used for the study:
- Name of test material:2-hydroxy-1H-isoindole-1,3(2H)-dione
- Molecular formula: C8H5NO3
- Molecular weight: 163.132 g/mol
- Smiles notation: c12c(C(=O)N(C1=O)O)cccc2
- Substance type: Organic
- Physical state: Solid
Type:
density
Density:
1.616 g/cm³
Temp.:
20 °C

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1stReading

2nd Reading

 

 

 

Method

Adapted from ASTM 854-02

 

 

 

Principle of method

The density of test item is determined by using pyknometer. It is the ratio of mass of the unit volume of test item at a stated temperature to mass of the same volume of gas free distilled water at a stated temperature.

 

 

 

Test temperature (°C)

-

20oC

20oC

 

Atmospheric pressure (in hPa)

-

976.2

977.8

 

Weight of empty dry pyknometer (Wp)

 

29.229

30.726

 

Weight of pyknometer filled with water (WA)

 

79.918

80.704

 

Weight of pyknometer + test Item (WPS)

 

35.051

35.918

 

Weight of pyknometer +test Item+ water (WB)

 

82.163

82.672

 

 

 

CALCULATIONS:

 

Calculated values

1st Calculation

2nd Calculation

 

Wo=WPS-WP

 

5.8220

 

5.1920

 

(WA-WB)

 

-2.2450

 

-1.9680

 

Specific gravity = WO/[WO+ (WA-WB)]

1.6276

1.6104

 

Specific Gravity; Gs

1.6276

1.6104

Density (g/cm³)

1.6246

1.6075

Mean Density (g/cm³)

1.6161

Conclusions:
The density of test item 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9)was determined following OECD Guideline 109 and according to the Adapted from ASTM D854-02 using glass pyknometer.The mean density of 2-hydroxy-1H-isoindole-1,3(2H)-dione was determined to be 1.616 g/cm³ at 20°C and 977.0 hPa.
Executive summary:

The density of test item 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9)was determined following OECD Guideline 109 and according to the Adapted from ASTM D854-02 using glass pyknometer.The mean density of 2-hydroxy-1H-isoindole-1,3(2H)-dione was determined to be 1.616 g/cm³ at 20°C and 977.0 hPa.

Description of key information

The density of test item 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9)was determined following OECD Guideline 109 and according to the Adapted from ASTM D854-02 using glass pyknometer.The mean density of 2-hydroxy-1H-isoindole-1,3(2H)-dione was determined to be 1.616 g/cm³ at 20°C and 977.0 hPa.

Key value for chemical safety assessment

Relative density at 20C:
1.616

Additional information

The density of test item 2-hydroxy-1H-isoindole-1,3(2H)-dione (CAS No. 524-38-9)was determined following OECD Guideline 109 and according to the Adapted from ASTM D854-02 using glass pyknometer.The mean density of 2-hydroxy-1H-isoindole-1,3(2H)-dione was determined to be 1.616 g/cm³ at 20°C and 977.0 hPa.

Other supporting studies from various reliable sources such as authoritative database and handbook also indicates that the density of chemical 2-hydroxy-1H-isoindole-1,3(2H)-dione was determined to be in the range of 1.58 g/cm3 to 1.601 g/cm3

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of density as 1.616 g/cm3 at 20 degree C, thus considered as key study for the chemical safety assessment.